Plasma and erythrocyte magnesium levels in patients with primary affective disorder during chronic lithium treatment

Plasma and erythrocyte magnesium concentrations were measured in 79 clinic outpatients who had histories of bipolar or unipolar primary affective disorder and who were being chronically treated with lithium carbonate (60 patients) or placebo (19 patients). Although slight differences in the mean con...

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Bibliographic Details
Published inActa psychiatrica Scandinavica Vol. 51; no. 2; p. 104
Main Authors Dunner, D L, Meltzer, H L, Schreiner, H C, Feigelson, J L
Format Journal Article
LanguageEnglish
Published United States 01.02.1975
Subjects
Adult
Aged
Bipolar Disorder - blood
Bipolar Disorder - drug therapy
Clinical Trials as Topic
Erythrocytes - drug effects
Erythrocytes - metabolism
Female
Humans
Lithium - administration & dosage
Lithium - pharmacology
Lithium - therapeutic use
Magnesium - blood
Magnesium - metabolism
Male
Middle Aged
Placebos
Sex Factors
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Summary:Plasma and erythrocyte magnesium concentrations were measured in 79 clinic outpatients who had histories of bipolar or unipolar primary affective disorder and who were being chronically treated with lithium carbonate (60 patients) or placebo (19 patients). Although slight differences in the mean concentration of magnesium in plasma and erythrocytes were noted with lithium treatment, diagnosis, and sex, the differences overall failed to achieve statistical significance. In contrast to prior reports demonstrating increases in plasma magnesium during acute lithium carbonate treatment of affectively ill patients, these data suggest that the pre-lithium steady state is achieved during chronic lithium treatment.
ISSN:0001-690X
DOI:10.1111/j.1600-0447.1975.tb00219.x