Suicide by Self‐Administration of a Drug Mixture (Propofol, Midazolam, and Zolpidem) in an Anesthesiologist: The First Case Report in Italy

• Published in: Journal of forensic sciences Vol. 58; no. 3; pp. 837 - 841
• Main Authors: Colucci, Anna Pia, Gagliano‐Candela, Roberto, Aventaggiato, Lucia, Donno, Antonio, Leonardi, Sabrina, Strisciullo, Giuseppe, Introna, Francesco
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.05.2013
• Subjects: Adipose Tissue - chemistry; Amitriptyline - analysis; anesthesiologist; Anesthesiology; Chromatography; Drug Combinations; forensic science; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Gastrointestinal Contents - chemistry; Hair - chemistry; Hair analysis; Humans; Hypnotics and Sedatives - analysis; Hypnotics and Sedatives - poisoning; Infusions, Intravenous; Italy; Male; Mass spectrometry; Midazolam - analysis; Midazolam - poisoning; Middle Aged; Physicians; Prescription Drug Misuse; propofol; Propofol - analysis; Propofol - poisoning; Pyridines - analysis; Pyridines - poisoning; Suicide; Suicides & suicide attempts; Thiopental - analysis; Tissues; Toxicology; zolpidem
• ISSN: 0022-1198; 1556-4029
• DOI: 10.1111/1556-4029.12053

The authors report an unusual case of suicide of an anesthesiologist, in which the suicide manner and means depend upon the victim's occupation. This is the first case report published in Italy of a death involving propofol and other drugs. The anesthesiologist was found dead with an empty drip still inserted in the hand and another one near his body. Forensic and toxicological findings suggested that the cause of death was a respiratory depression due to a self‐administration of a rapidly infused lethal drug mixture. Analytical drug quantification was performed by gas chromatography‐mass spectrometry. Blood analysis revealed: zolpidem (0.86 μg/mL), propofol (0.30 μg/mL), midazolam (0.08 μg/mL), thiopental (0.03 μg/mL), and amitriptyline (0.07 μg/mL). Adipose tissue and hair analysis suggested a previous and repeated use of these drugs verifying the fact that in Italy recreational abuse of anesthetic and sedative agents in health care practitioners is becoming an increasing problem.