HIV-disease and bone marrow changes: a study of 60 cases

We report our experience of peripheral blood and bone marrow changes in patients with HIV disease. Abnormalities were most commonly seen in patients with advanced disease. In AIDS group IV patients (CDC classification) anaemia (92%) neutropenia (85%) monocytopenia (75%) and thrombocytopenia (61%) ha...

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Bibliographic Details
Published inEuropean journal of haematology Vol. 42; no. 4; p. 339
Main Authors Mir, N, Costello, C, Luckit, J, Lindley, R
Format Journal Article
LanguageEnglish
Published England 01.04.1989
Subjects
Acquired Immunodeficiency Syndrome - complications
Acquired Immunodeficiency Syndrome - pathology
Adult
AIDS-Related Complex - pathology
Anemia - etiology
Bone Marrow - pathology
Cytoplasmic Granules - pathology
Erythrocytes - pathology
Erythropoiesis
Female
Granulocytes - pathology
Hematopoiesis
Humans
Leukopenia - etiology
Lymphocytes - pathology
Male
Middle Aged
Monocytes - pathology
Plasma Cells - pathology
Sarcoma, Kaposi - pathology
Thrombocytopenia - etiology
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Summary:We report our experience of peripheral blood and bone marrow changes in patients with HIV disease. Abnormalities were most commonly seen in patients with advanced disease. In AIDS group IV patients (CDC classification) anaemia (92%) neutropenia (85%) monocytopenia (75%) and thrombocytopenia (61%) have their highest incidence, the reason being a combination of factors such as infection, myelosuppressive drugs and HIV infection itself. Bone marrow examinations were performed most commonly for microbiological culture (25%) and the investigation of anaemia (16%). Morphological changes in the bone marrow were non-specific and not pathognomic; however erythroid hypoplasia was found to be a distinctive feature associated with MAI infection. The procedure provided a high yield for microbiological culture, particularly in MAI infection.
ISSN:0902-4441
DOI:10.1111/j.1600-0609.1989.tb01222.x