Rosiglitazone is effective and well-tolerated in a range of therapeutic regimens during daily practice in patients with type 2 diabetes

• Published in: International journal of clinical practice (Esher) Vol. 60; no. 9; pp. 1040 - 1047
• Main Authors: ROSAK, C., STANDL, E., REBLIN, T., STAMMER, H., SEIDEL, D. K.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.2006; Blackwell
• Subjects: Biological and medical sciences; Blood Glucose - metabolism; Blood Pressure - drug effects; combination therapy; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Drug Therapy, Combination; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; General aspects; glycaemic control; Humans; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - adverse effects; Male; Medical sciences; Middle Aged; Rosiglitazone; Thiazolidinediones - administration & dosage; Thiazolidinediones - adverse effects; type 2 diabetes; Weight Loss - drug effects; Endocrinopathy; Type 2 diabetes; Human; Drug combination; Check; Metabolic diseases; Patient; Thiazolidinedione derivatives; Medicine; Hypoglycemic agent; Daily; Regulation(control); Surveillance; Efficiency; Professional practice; Rosiglitazone; combination therapy; Combined treatment; glycaemic control; Glycemia
• ISSN: 1368-5031; 1742-1241
• DOI: 10.1111/j.1742-1241.2006.01092.x

Subjects (N = 22,808) with inadequately controlled type 2 diabetes mellitus (T2DM) were included in a large 6‐month observational study in Germany. Rosiglitazone (RSG) was added to existing therapy in line with daily practice, with 19,962 subjects evaluated for efficacy by treatment group: RSG monotherapy (n = 1017), RSG plus metformin (MET) (n = 7160), RSG plus sulphonylurea (n = 5033), triple oral therapy (n = 4247), and the remaining subject population (n = 2505). Overall, RSG significantly reduced median HbA1c and fasting blood glucose by 1.3% and 50 mg/dl over 6 months (p < 0.001 for both). The proportion of subjects achieving glycaemic goals of ≤ 6.5% and ≤ 7.0% increased from 5.7% to 33.8%, and from 13.9% to 55.5%, respectively (p < 0.001 for both). Mean systolic and diastolic blood pressures were reduced in the total subject population by 6 mmHg and 2 mmHg, respectively (p < 0.001 for both). RSG had a neutral or reductive effect on mean weight of most (69%) subjects. Consistent with clinical trial data, RSG mono‐ or combination therapy improved glycaemic control when used in daily clinical practice and is generally well‐tolerated.