Immediate colposcopic evaluation in postmenopausal women with low-grade squamous intraepithelial lesion cytology

• Published in: Acta obstetricia et gynecologica Scandinavica Vol. 91; no. 9; pp. 1109 - 1113
• Main Authors: AKBAYIR, OZGUR, CILESIZ GOKSEDEF, BEHIYE PINAR, NUMANOĞLU, CEYHUN, CORBACIOGLU, AYTUL, ULKER, VOLKAN, AKYOL, ALPASLAN, GÜRASLAN, HAKAN, CETIN, AHMET, GULKILIK, AHMET
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.2012; Blackwell
• Subjects: Aged; Biological and medical sciences; Carcinoma, Squamous Cell - pathology; Cervical Intraepithelial Neoplasia - pathology; Colposcopy; Cytological Techniques; Female; Gynecology. Andrology. Obstetrics; human papilloma virus; Humans; Low-grade squamous intraepithelial lesion; Medical sciences; Middle Aged; Neoplasm Grading; postmenopausal woman; Postmenopause; premenopausal woman; Retrospective Studies; Uterine Cervical Dysplasia - pathology; Uterine Cervical Neoplasms - pathology; Human; postmenopausal woman; Low-grade squamous intraepithelial lesion; Colposcopy; Gynecology; Cytology; human papilloma virus; Obstetrics; Virus; premenopausal woman; Young adult; Squamous intraepithelial lesion; Postmenopause; Female; Papilloma; Benign neoplasm; Woman
• ISSN: 0001-6349; 1600-0412
• DOI: 10.1111/j.1600-0412.2012.01452.x

Objective. To compare the final diagnosis among pre‐ and postmenopausal women with low‐grade squamous intraepithelial lesion (LGSIL) cervical smear results. Design. Retrospective, comparative study. Setting. Departments of obstetrics and gynecology in two teaching and research hospitals. Population. Data were evaluated on 712 women with LGSIL between April 2005 and April 2011. Methods. Results from 129 postmenopausal women with LGSIL were compared with 583 premenopausal women with a similar LGSIL result with respect to sociodemographic data and histopathology. Main outcome measures. Final clinicopathological diagnosis. Results. The mean age of the pre‐ and postmenopausal women was 37.2 and 52.5 years, respectively, and lesions of cervical intraepithelial neoplasia grade 2 or worse were detected by biopsy and/or endocervical curettage in 13.6 and 9.3%, respectively. There was no significant difference between the final diagnosis among pre‐ and postmenopausal women with LGSIL cytology (relative risk 1.43; 95% confidence interval 0.82–2.48; p= 0.19). Invasive cervical cancer was detected in three premenopausal (0.5%) and two postmenopausal women (1.6%). Conclusions. Cervical pre‐invasive and invasive disease rates were similar in pre‐ and postmenopausal women with LGSIL cytology. For this reason, LGSIL in postmenopausal women should be considered more seriously, and colposcopic evaluation may be as acceptable an option in the management of LGSIL in this group of patients as it is with premenopausal women.