Osteoprotegerin gene polymorphism in diabetic Charcot neuroarthropathy

• Published in: Diabetic medicine Vol. 29; no. 6; pp. 771 - 775
• Main Authors: Korzon-Burakowska, A., Jakóbkiewicz-Banecka, J., Fiedosiuk, A., Petrova, N., Koblik, T., Gabig-Cimińska, M., Edmonds, M., Małecki, M. T., Węgrzyn, G.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2012; Blackwell
• Subjects: Adult; Arthropathy, Neurogenic - blood; Arthropathy, Neurogenic - epidemiology; Arthropathy, Neurogenic - genetics; Biological and medical sciences; Charcot neuroarthropathy; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - epidemiology; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - genetics; Diabetes. Impaired glucose tolerance; diabetic foot; Diabetic Neuropathies - blood; Diabetic Neuropathies - epidemiology; Diabetic Neuropathies - genetics; diabetic neuropathy; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Genetic Predisposition to Disease; Genotype; Humans; Male; Medical sciences; Middle Aged; Osteoprotegerin - blood; Osteoprotegerin - genetics; osteoprotegerin gene; Poland - epidemiology; polymorphism; Polymorphism, Single Nucleotide; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; Poland; Endocrinopathy; Human; Obesity; Skin disease; Nervous system diseases; Nutrition; Diabetic Foot; Charcot neuroarthropathy; diabetic neuropathy; Diabetes mellitus; Nutrition disorder; osteoprotegerin gene; Metabolic diseases; Neuropathy; Osteoprotegerin; Gene; Disease of the foot; Genetics; Endocrinology; Nutritional status; Polymorphism
• ISSN: 0742-3071; 1464-5491; 1464-5491
• DOI: 10.1111/j.1464-5491.2011.03442.x

Diabet. Med. 29, 771–775 (2012) Aims  Recently, an association between two polymorphisms (1181G>C and 245T>G) of the osteoprotegerin (OPG) gene and diabetic Charcot neuroarthropathy was suggested on the basis of studies of a limited number of samples derived from subjects from one geographical region (Italy). The aim of this study was to assess the presence of various osteoprotegerin gene polymorphisms in patients with diabetes and Charcot neuroarthropathy compared with subjects with diabetic neuropathy but no Charcot foot and healthy controls from another geographical region (Poland). Methods  DNA was isolated from 54 patients with Charcot neuroarthropathy, 35 subjects with diabetic neuropathy but no Charcot foot, and 95 healthy controls to evaluate OPG gene polymorphisms and their possible contribution to the development of Charcot neuroarthropathy. Results  Statistically significant differences between the group of subjects with neuropathy but no Charcot neuroarthropathy and the control group were found for 1217C>T, 950T>C and 245T>G polymorphisms, between the group of patients with Charcot neuroarthropathy and the control group for 1181G>C and 950T>C polymorphisms, and between the group of subjects with neuropathy but no Charcot neuroarthropathy and the group of patients with Charcot neuroarthropathy for 1217C>T and 245T>G polymorphisms. Conclusion  We suggest that genetic factors, particularly OPG gene polymorphisms, may play a role in the development of diabetic Charcot neuroarthropathy.