Chronic alcohol ingestion decreases pituitary-thyroid axis measures in Fischer-344 rats

In a chronic feeding study adult male Fischer-344 rats (n = 12) were fed a nutritionally complete liquid diet containing 10% (w/v) ethanol for 40 days while control animals (n = 12) were pair fed a nutritionally complete isocaloric diet in which dextrose was substituted for ethanol. Treated animals...

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Bibliographic Details
Published inAlcoholism, clinical and experimental research Vol. 12; no. 6; p. 731
Main Authors Mason, G A, Stanley, D A, Walker, C H, Hashimoto, H, Noonan, L R, Prange, Jr, A J
Format Journal Article
LanguageEnglish
Published England 01.12.1988
Subjects
Alcoholism - blood
Animals
Hypothalamo-Hypophyseal System - drug effects
Male
Rats
Rats, Inbred F344
Thyroid Gland - drug effects
Thyroid Hormones - blood
Thyrotropin - blood
Thyrotropin-Releasing Hormone
Triiodothyronine - blood
Triiodothyronine, Reverse - blood
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Summary:In a chronic feeding study adult male Fischer-344 rats (n = 12) were fed a nutritionally complete liquid diet containing 10% (w/v) ethanol for 40 days while control animals (n = 12) were pair fed a nutritionally complete isocaloric diet in which dextrose was substituted for ethanol. Treated animals were gradually introduced to and withdrawn from the 10% diet. At the end of the study and at sacrifice ethanol-fed rats had gained slightly more weight than pair-fed controls. They also showed a significant decrease in total thyroxine, free thyroxine, L-triiodothyronine, reverse L-triiodothyronine, and basal thyroid-stimulating hormone. These differences did not appear to result from caloric deprivation alone. Possible explanations for some of these thyroidal changes are discussed.
ISSN:0145-6008
DOI:10.1111/j.1530-0277.1988.tb01336.x