The lipid profile in psoriasis: a controlled study

• Published in: Journal of the European Academy of Dermatology and Venereology Vol. 21; no. 10; pp. 1330 - 1332
• Main Authors: Akhyani, M, Ehsani, AH, Robati, RM, Robati, AM
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.11.2007
• Subjects: Adult; Case-Control Studies; Female; Humans; lipid; Lipids - blood; Male; Phenotype; psoriasis; Psoriasis - blood; Reference Values; serum
• ISSN: 0926-9959; 1468-3083
• DOI: 10.1111/j.1468-3083.2007.02260.x

Background  Psoriasis is an inflammatory dermatosis that is characterized with hyperproliferation of keratinocytes and inflammatory infiltration in the epidermis and dermis. The high prevalence of atherosclerosis has been reported in psoriatic patients. High serum lipid level has been suggested in the pathogenesis of this phenomenon. In this study, our purpose was to compare the lipid profile in psoriatic patients with non‐affected persons. Methods  This study was designed and conducted as a case–control assay with 50 cases in the patient and control groups, respectively. The lipid profile, including serum level of triglyceride, cholesterol, low‐density lipoprotein (LDL), and high‐density lipoprotein (HDL), were assessed in both groups. Results  The patient and control groups each consisted of 50 cases (39 male and 11 female). The serum triglyceride, cholesterol, and LDL was significantly higher in psoriatic patients (P < 0.05) but not for HDL (P = 0.29). Conclusion  This study, like previous assays, shows that high serum lipid level is significantly more common in psoriasis. This fact may be responsible for higher prevalence of cardiovascular accident in psoriatic patients. It may be useful to do early screening and treatment of hyperlipidaemia in psoriasis to prevent the atherosclerosis and its complications.