A Multicenter Study of the Prevalence of Dry Eye Disease in Chinese Refractive Surgery Candidates

• Published in: Ophthalmic research Vol. 64; no. 2; pp. 224 - 229
• Main Authors: Li, Meiyan, Zeng, Li, Mi, Shengjian, Li, Ying, Liu, Zhirong, Yu, Keming, Hu, Qi, Li, Haiyan, Ma, Daijin, Zhou, Yuehua, Wang, Jibing, Guo, Xiaomei, Fang, Xuejun, Bai, Ji, Choi, Joanne, Zhou, Xingtao
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.03.2021
• Subjects: Analysis; Eye; Eye diseases; Fluorescein; Health aspects; Prevalence studies (Epidemiology); Research Article; Surgery; China; Tear film breakup time; Dry eye; Contact lens; Keratorefractive surgery; Schirmer test
• ISSN: 0030-3747; 1423-0259; 1423-0259
• DOI: 10.1159/000509060

Objective: The aim of this study was to determine the prevalence of preoperative dry eye disease and evaluate tear film function in refractive surgery candidates in China. Methods: In this prospective noninterventional cross-sectional study, refractive surgical candidates from 13 preselected eye hospitals in China were recruited from July 2015 to February 2016. Patient histories, subjective symptoms, tear film breakup time (TBUT), ocular surface fluorescein staining, and Schirmer I tests (SIT), were assessed to conduct subgroup analysis. Results: A total of 1,849 patients were recruited, 41.4% were diagnosed with dry eye disease (766/1,849) and 44.9% (830/1,849) of subjects had a positive history of contact lens (CL) wear. The overall mean TBUT and SIT values were 7.3 ± 3.7 s and 15.2 ± 8.8 mm, respectively. The total prevalence of ocular surface fluorescein staining was 23.46% (422/1,849); 44.62% of patients had TBUT <5 s and 23.20% of patients had SIT <5 mm. CL wearers were observed to have a higher prevalence of dry eye than non-CL wearers (54.1 vs. 35.2%, OR = 2.17, 95% CI: 1.77–2.65). Conclusions: In this study, the most common abnormal finding in dry eye disease was tear film instability. A high proportion of refractive surgery candidates have preexisting dry eye disease and a history of CL wear prior to surgery. Careful attention should be given to the evaluation of preoperative dry eye in refractive surgery candidates.