New Schiartane-type Triterpene from Kadsura heteroclita and their Cytotoxic Activities

• Published in: Natural product communications Vol. 9; no. 3; pp. 373 - 374
• Main Authors: Minh, Pham Thi Hong, Lam, Do Tien, Tien, Nguyen Quyet, Tuan, Nguyen Ngoc, Nhung, Vu Phuong, Van Hai, Nong, Van Kiem, Phan, Nhiem, Nguyen Xuan, Van Minh, Chau, Ju, Park Seon, Hyun, Kim Seung
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.03.2014
• Subjects: Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Drug Screening Assays, Antitumor; HT29 Cells; Humans; Kadsura - chemistry; Molecular Structure; Triterpenes - chemistry; Triterpenes - isolation & purification; Heteroclitalactone N; Kadsura heteroclita; Schisandraceae; Cytotoxic activity
• ISSN: 1934-578X; 1555-9475
• DOI: 10.1177/1934578X1400900324

One new schiartane-type triterpene, heteroclitalactone N (1), and four known compounds (2–5), seco-coccinic acid F, dihydroguaiaretic acid, schizanrin F, and kadsuralignan B were isolated from the stems of Kadsura heteroclita. Their structures were determined by the combination of spectroscopic and chemical methods, including 1D-, 2D-NMR, and CD spectra as well as by comparing with the NMR data reported in the literature. The cytotoxic activities of all isolated compounds were evaluated on three human cancer cell lines. Compound 3 exhibited moderate to weak cytotoxic activities on three human cancer cell lines, OVCAR, HT-29, and A-549, with IC50 values ranging from 16.2 to 36.4 μM.