Research progress of meliaceous limonoids from 2011 to 2021
Covering: July 2010 to December 2021 Limonoids, a kind of natural tetranortriterpenoids with diverse skeletons and valuable insecticidal and medicinal bioactivities, are the characteristic metabolites of most plants of the Meliaceae family. The chemistry and bioactivities of meliaceous limonoids are...
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| Published in | Natural product reports Vol. 39; no. 6; pp. 1325 - 1365 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
22.06.2022
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Covering: July 2010 to December 2021
Limonoids, a kind of natural tetranortriterpenoids with diverse skeletons and valuable insecticidal and medicinal bioactivities, are the characteristic metabolites of most plants of the Meliaceae family. The chemistry and bioactivities of meliaceous limonoids are a continuing hot area of natural products research; to date, about 2700 meliaceous limonoids have been identified. In particular, more than 1600, including thirty kinds of novel rearranged skeletons, have been isolated and identified in the past decade due to their wide distribution and abundant content in Meliaceae plants and active biosynthetic pathways. In addition to the discovery of new structures, many positive medicinal bioactivities of meliaceous limonoids have been investigated, and extensive achievements regarding the chemical and biological synthesis have been made. This review summarizes the recent research progress in the discovery of new structures, medicinal and agricultural bioactivities, and chem/biosynthesis of limonoids from the plants of the Meliaceae family during the past decade, with an emphasis on the discovery of limonoids with novel skeletons, the medicinal bioactivities and mechanisms, and chemical synthesis. The structures, origins, and bioactivities of other new limonoids were provided as ESI. Studies published from July 2010 to December 2021 are reviewed, and 482 references are cited.
In this review, the recent progress in the discovery of new structures, bioactivities, and synthesis of limonoids from plants of the Meliaceae family have been summarized. |
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| Bibliography: | https://doi.org/10.1039/d2np00015f Yunpeng Sun finished his Bachelor's degree in Pharmacy (2016) and Master's degree in Medicinal Chemistry (2019) at Anhui University of Chinese Medicine. After graduation, he joined the research group of Professor Lingyi Kong at China Pharmaceutical University as a doctoral candidate. He has been working on the discovery and identification of biologically active limonoids from Meliaceae plants. Professor Lingyi Kong received his PhD in Medicinal Chemistry in 1992 from Shenyang College of Pharmacy, and continued his two-year postdoctoral research at China Pharmaceutical University, where he has been working ever since. He was promoted to full professor (1997), Dean of the School of Traditional Chinese Pharmacy (1997-2012), and has been Vice-President since 2013. He was a visiting scholar at Meijo University, Japan (1998-1999), and a visiting professor at Kyushu University, Japan (2009). His main research directions include isolation, structure determination, biological activity and mechanisms, discovery of new drug targets, and the R&D of innovative drugs based on bioactive natural products from traditional Chinese medicines and other natural sources. Qiurong Li received her bachelor's degree in Chengdu University of Traditional Chinese Medicine (2019). After graduation, she joined the research group of Professor Kong Lingyi at China Pharmaceutical University to study for a master's degree. She has been working on the antiinflammatory activity of meliaceous limonoids. Professor Jun Luo received his PhD degree in Traditional Chinese Pharmacology (2010) from China Pharmaceutical University (CPU) under the supervision of Professor Lingyi Kong. He worked at the School of Traditional Chinese Pharmacy of CPU after graduation, as a visiting scholar at the Scripps Research Institute in 2017, and was promoted to Full Professor in 2018. His research interests have focused on the discovery and biosynthesis of antiinflammatory terpenoid derivatives, especially meliaceous limonoids, from traditional Chinese medicine and Chinese folk medicine. Electronic supplementary information (ESI) available. See ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ISSN: | 0265-0568 1460-4752 1460-4752 |
| DOI: | 10.1039/d2np00015f |