Dietary arginine supplementation enhances immune responses to inactivated Pasteurella multocida vaccination in mice

• Published in: British journal of nutrition Vol. 109; no. 5; pp. 867 - 872
• Main Authors: Ren, Wenkai, Zou, Lingxiu, Li, Nengzhang, Wang, Yan, Liu, Gang, Peng, Yuanyi, Ding, Jiannan, Cai, Lichuang, Yin, Yulong, Wu, Guoyao
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 14.03.2013
• Subjects: Adjuvants, Immunologic - administration & dosage; Amino acids; Animals; Antibodies, Bacterial - blood; Arginine - administration & dosage; Bacteria; Bacterial Vaccines - immunology; Biological and medical sciences; Cytokines - blood; Dietary Supplements; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Glutathione Peroxidase - blood; Immune system; Immunity, Active - immunology; Immunization; Mice; Nutritional Immunology; Pasteurella Infections - prevention & control; Pasteurella multocida; Pasteurella multocida - immunology; Rodents; Vaccines, Inactivated - immunology; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Adjuvants; Arginine; Nutrition; Pasteurella multocida; Immune response; Vaccination; Rodentia; Feeding; Arginine: Pasteurella multocida; Vertebrata; Mammalia; Mouse; Animal; Supplementation

The present study was conducted to determine the adjuvant effect of arginine in mice immunised with inactivated vaccine. Mice immunised with an inactivated Pasteurella multocida vaccine and fed diets supplemented with 0·2 % (vaccine-0·2 %) or 0·5 % (vaccine-0·5 %) arginine exhibited 100 % protection...