Antibody titers to pseudorabies virus in piglets immunized with gIII deleted pseudorabies vaccine in a pseudorabies infected herd

• Published in: Veterinary microbiology Vol. 42; no. 4; pp. 341 - 348
• Main Authors: Elvinger, François, Reeves, David E., Pursell, Alfred R., Cole, John R., Liauw, Hardi
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.12.1994; Elsevier Science
• Subjects: Animals; Animals, Newborn; ANTIBODIES; Antibodies, Viral - blood; ANTICORPS; ANTICUERPOS; AUJESZKY'S DISEASE; Biological and medical sciences; CERDO; ENFERMEDAD DE AUJESZKY; Female; Fundamental and applied biological sciences. Psychology; Herpesvirus 1, Suid - immunology; HERPETOVIRIDAE; IMMUNE RESPONSE; Immunity, Maternally-Acquired - immunology; MALADIE D'AUJESZKY; Microbiology; Pig / pseudorabies virus; PORCIN; Pseudorabies - immunology; Pseudorabies - prevention & control; Pseudorabies Vaccines; Pseudorabies virus; REPONSE IMMUNITAIRE; RESPUESTA INMUNOLOGICA; SWINE; Swine Diseases - immunology; Swine Diseases - prevention & control; Time Factors; VACCINATION; Vaccination / pseudorabies virus; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies; Vaccines, Attenuated - administration & dosage; Vaccines, Attenuated - immunology; VACUNACION; Viral Vaccines - administration & dosage; Viral Vaccines - immunology; Virology; Pseudorabies virus; Immune response; Vaccination / pseudorabies virus; Pig / pseudorabies virus; Immunization; Antibody; Herpesviridae; Alphaherpesvirinae; Vaccine; Veterinary medicine; Infection; Virus; Aujeszky virus; Vertebrata; Aujeszky disease; Mammalia; Swine; Viral disease; Artiodactyla; Ungulata; Humoral immunity
• ISSN: 0378-1135; 1873-2542
• DOI: 10.1016/0378-1135(94)90065-5

The decrease in titer of PRV antibodies in serum was evaluated at 10, 37, 67, 109 and 173 days of age in 16 non-vaccinated pigs and 43 pigs vaccinated at 3, 67 and 80 days of age with a modified live TK/gIII gene deleted pseudorabies virus (PRV) vaccine. Serum samples were analyzed for antibodies to PRV by the serum-virus neutralization test (SN), a commercial competitive ELISA (CELISA), and the CELISA OMNIMARK PRV differential (OMD) diagnostic kit. At 10 days of age, all pigs had SN titers ≥ 1:4 and were CELISA+/OMD+, indicating circulating antibodies to field strains of PRV. At 109 days, all non-vaccinated pigs had SN titers < 1:4. Forty-five percent of vaccinated pigs had SN titers ≥ 1:4, 56% were CELISA positive and most were CELISA+/OMD−, indicating antibodies due to vaccination. At 24 weeks of age, all pigs had SN titers ≥ 1:4 and were CELISA+/OMD+ due to exposure to field strains. Although circulating maternal antibodies interfere with the development of active immunity, vaccination at 3 days of age resulted in detectable antibodies by 67 days of age, and a limited immune response could be measured at 109 days of age.