Differential effects of subcutaneous estrogen and progesterone on low-density lipoprotein size and susceptibility to oxidation in postmenopausal rhesus monkeys
Objective: To study the differential effects of subcutaneous E 2 alone or in combination with P on the susceptibility of low-density lipoprotein (LDL) cholesterol to oxidation in naturally postmenopausal diet-controlled rhesus monkeys. Design: Prospective, longitudinal controlled study. Setting: Ore...
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Published in | Fertility and sterility Vol. 68; no. 3; pp. 525 - 530 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York, NY
Elsevier Inc
01.09.1997
Elsevier Science |
Subjects | |
Online Access | Get full text |
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Summary: | Objective: To study the differential effects of subcutaneous E
2 alone or in combination with P on the susceptibility of low-density lipoprotein (LDL) cholesterol to oxidation in naturally postmenopausal diet-controlled rhesus monkeys.
Design: Prospective, longitudinal controlled study.
Setting: Oregon Health Sciences University, Portland, Oregon, and Oregon Regional Primate Research Center, Beaverton, Oregon.
Patient(s): Five naturally postmenopausal rhesus monkeys.
Intervention(s): Estradiol was administered subcutaneously for the first 4 weeks, followed by E
2 plus P for 4 weeks, followed by a third 4-week washout period.
Main Outcome Measure(s): Changes in plasma lipoprotein levels and oxidation of LDL and serum concentrations of E
2 and P.
Result(s): Levels of LDL cholesterol fell after 4 weeks of treatment with E
2, compared with baseline. The lag time to half maximal light absorbancy after 4 weeks of E
2 treatment was significantly increased compared with baseline. The maximal absorbance values and the slope of the propagation phase after 4 weeks of treatment with E
2 were decreased compared with baseline. After 4 weeks of combined E
2 and P treatment, all values were comparable to baseline.
Conclusion(s): These results suggest that subcutaneous E
2 therapy appears to enhance LDL resistance to oxidation and that this effect is attenuated by the addition of the P. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0015-0282 1556-5653 |
DOI: | 10.1016/S0015-0282(97)00237-9 |