GNAS and KRAS mutational analyses of intraductal papillary neoplasms of the pancreas and bile duct developing in the same individual: A case report

• Published in: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Vol. 15; no. 6; pp. 713 - 716
• Main Authors: Date, Kenjiro, Ohtsuka, Takao, Fujimoto, Takaaki, Gotoh, Yoshitaka, Nakashima, Yohei, Kimura, Hideyo, Matsunaga, Taketo, Mori, Yasuhisa, Mochidome, Naoki, Miyazaki, Tetsuyuki, Oda, Yoshinao, Tanaka, Masao, Nakamura, Masafumi
• Format: Journal Article
• Language: English
• Published: Switzerland Elsevier India Pvt Ltd 01.11.2015; Elsevier Limited
• Subjects: Aged; Antigens; Bile; Bile duct neoplasm; Bile Duct Neoplasms - genetics; Bile Duct Neoplasms - pathology; Bile Duct Neoplasms - surgery; Carcinoma, Pancreatic Ductal - genetics; Carcinoma, Pancreatic Ductal - pathology; Carcinoma, Pancreatic Ductal - surgery; Cellular biology; Chemotherapy; Chemotherapy, Adjuvant; Chromogranins; Classification; Endocrinology & Metabolism; Endoscopy; Fatal Outcome; Female; Gastroenterology and Hepatology; GNAS; GTP-Binding Protein alpha Subunits, Gs - genetics; GTP-Binding Protein alpha Subunits, Gs - metabolism; Humans; Intraductal papillary neoplasm; IPMN; KRAS; Morphology; Mutation; Neoplasm Invasiveness; Pancreas; Pancreas neoplasm; Pancreatectomy; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - pathology; Pancreatic Neoplasms - surgery; Proto-Oncogene Proteins p21(ras) - genetics; Proto-Oncogene Proteins p21(ras) - metabolism; Rodents; Studies; Tumors; Ultrasonic imaging; GNAS; KRAS; IPMN; Intraductal papillary neoplasm; Pancreas neoplasm; Bile duct neoplasm
• ISSN: 1424-3903; 1424-3911
• DOI: 10.1016/j.pan.2015.09.013

Abstract Intraductal papillary mucinous neoplasm (IPMN) of the pancreas and intraductal papillary neoplasm of the bile duct (IPNB) are considered as counterparts of each other, and it is suggested that these two entities have similar molecular alteration pathways. However, the occurrence of IPMN of the pancreas and IPNB in the same patient is rare. We report a surgical case of a 69-year-old woman who developed invasive IPMN of the pancreas and underwent pancreatectomy, 6 months after hepatic resection of invasive IPNB. Molecular analysis revealed GNAS / KRAS mutation in both invasive IPMN of the pancreas and IPNB. This is believed to be the first case report investigating GNAS / KRAS mutational status in both IPMN of the pancreas and IPNB developing in the same patient, and these two entities may show similar molecular alternations.