Up-regulation of Human Leukocyte Antigen G Expression in Primary Cutaneous Malignant Melanoma Associated with Host-vs-tumor Immune Response

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 28; no. 2; pp. 219 - 221
• Main Author: 方险峰 张序心 李家文
• Format: Journal Article
• Language: English
• Published: Heidelberg Huazhong University of Science and Technology 01.04.2008; Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China%The First College of Clinical Medicine Sciences, Three Georges University, Yichang 443003, China
• Subjects: Cell Nucleus - metabolism; Cytoplasm - metabolism; Gene Expression Regulation, Neoplastic; HLA Antigens - biosynthesis; HLA Antigens - metabolism; Humans; Immunohistochemistry; Inflammation; Leukocytes, Mononuclear - metabolism; Medicine; Medicine & Public Health; Melanoma - metabolism; Proto-Oncogene Proteins c-bcl-2 - metabolism; Skin - metabolism; Skin Neoplasms - metabolism; Transcriptional Activation; 恶性黑素瘤; 抗原体; 白细胞; human leukocyte antigen G; cutaneous malignant melanoma
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-008-0227-1

Human leukocyte antigen G （HLA-G） is one of the molecules implicated in immunotolerance. To investigate the role of HLA-G in primary cutaneous malignant melanoma （CMM）, a series of 47 skin melanocytic lesions were immunohistochemically evaluated. The correlation between HLA-G expression and CMM clinicohistopahtological data and Bcl-2 expression was also analyzed. HLA-G expression was detected in a variety of cell types. No significant difference in HLA-G expression was observed between malignant and non-malignant melanocytic lesions. HLA-G expression was significantly correlated with the inflammatory infiltration and Bcl-2 expression, whereas no significant correlation with ulceration, tumor thickness, clinical stage, histopathological subtypes were observed. HLA-G expression may be the result of host immune reaction in tumor microenvironment rather than a malignant feature of CMM.