Lipid and lipoprotein levels remain stable in acute ischemic stroke: the Northern Manhattan Stroke Study

• Published in: Atherosclerosis Vol. 139; no. 2; pp. 391 - 399
• Main Authors: Kargman, D.E, Tuck, C, Berglund, L, Lin, I.-F, Mukherjee, R.S, Thompson, E.V, Jones, J, Boden-Albala, B, Paik, M.C, Sacco, R.L
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ireland Ltd 01.08.1998; Elsevier
• Subjects: Acute Disease; Acute phase reactants; Acute-Phase Reaction - metabolism; Aged; Biological and medical sciences; Biomarkers; Brain Ischemia - blood; C-Reactive Protein - analysis; Cerebrovascular Disorders - blood; Female; Haptoglobins - analysis; Humans; Lipids; Lipids - blood; Lipoprotein(a); Lipoproteins - blood; Male; Medical sciences; Middle Aged; Neurology; Nutritional Status; Orosomucoid - analysis; Pilot Projects; Serum Albumin - metabolism; Stroke; Vascular diseases and vascular malformations of the nervous system; United States; North America; America; Lipids; Stroke; Lipoprotein(a); Acute phase reactants; Human; Nervous system diseases; Acute; Cardiovascular disease; Lipoprotein a; Cerebral disorder; Vascular disease; Follow up study; Central nervous system disease; Risk factor; Serum; Cerebrovascular disease
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/S0021-9150(98)00085-9

Serum lipoproteins including lipoprotein(a), Lp(a), are emerging as possible biological markers for cerebrovascular disease. Existing data on Lp(a) and serum lipids levels following acute ischemic stroke (AIS) are however equivocal. To determine whether serum Lp(a) and other lipid levels obtained within 24 h of acute ischemic stroke onset changed over the ensuing 4 weeks and whether these levels are related to an acute phase response, acquired nutritional deficiency, and neurovascular data, we conducted repeated measurement analyses among 19 subjects (mean age 65.0±12.1 years; 32% women) presenting with AIS (evaluated within 9.7±12.7 h). Eleven of the subjects had a moderate-to-severe stroke, defined by NIH stroke severity scale, and seven patients had a large cerebral infarction. Seven serial measurements of Lp(a), total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, and other lipoproteins, major acute phase reactants and albumin levels were collected for each subject over 4 weeks. The mean initial levels, (mg/dl), of total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, Lp(a), apolipoproteins A-I and B were: 225±57.6, 154±56.0, 40±10.4, 181±93.7, 52±28.6, 130±24.6, and 141±46.1, respectively. There were no significant changes in mean serum lipid, apolipoprotein or Lp(a) levels over the 4-week study period, analyzed by a random effects model to test for time trend. In addition, there were no significant changes in established acute phase or nutritional markers (C-reactive protein, alpha 1-glycoprotein, haptoglobin or serum albumin). Our findings suggest that serum lipid, apolipoprotein and Lp(a) levels remain stable following AIS, consistent with the absence of acute phase response or nutritional deficiency.