Chloroplast genome analysis and evolutionary insights in the versatile medicinal plant Calendula officinalis L

• Published in: Scientific reports Vol. 14; no. 1; p. 9662
• Main Authors: Zhang, Ningyun, Huang, Kerui, Xie, Peng, Deng, Aihua, Tang, Xuan, Jiang, Ming, Mo, Ping, Yin, Hanbin, Huang, Rongjie, Liang, Jiale, He, Fuhao, Liu, Yaping, Hu, Haoliang, Wang, Yun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.04.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/208; 631/208/726; Adaptation; Base Composition; Calendula - genetics; Calendula officinalis; Chloroplast genome; Chloroplasts; Chloroplasts - genetics; Codon Usage; Codon usage bias; Divergence; Ecological adaptation; Evolution; Evolution & development; Evolution, Molecular; Genetic diversity; Genome, Chloroplast; Genomes; Herbal medicine; Humanities and Social Sciences; Medicinal plants; multidisciplinary; Phylogenetics; Phylogeny; Plants, Medicinal - genetics; Science; Science (multidisciplinary); Evolution; Codon usage bias; Chloroplast genome; Adaptation; Calendula officinalis
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-60455-2

Calendula officinalis L.is a versatile medicinal plant with numerous applications in various fields. However, its chloroplast genome structure, features, phylogeny, and patterns of evolution and mutation remain largely unexplored. This study examines the chloroplast genome, phylogeny, codon usage bias, and divergence time of C. officinalis , enhancing our understanding of its evolution and adaptation. The chloroplast genome of C. officinalis is a 150,465 bp circular molecule with a G + C content of 37.75% and comprises 131 genes. Phylogenetic analysis revealed a close relationship between C. officinalis , C. arvensis , and Osteospermum ecklonis . A key finding is the similarity in codon usage bias among these species, which, coupled with the divergence time analysis, supports their close phylogenetic proximity. This similarity in codon preference and divergence times underscores a parallel evolutionary adaptation journey for these species, highlighting the intricate interplay between genetic evolution and environmental adaptation in the Asteraceae family. Moreover unique evolutionary features in C. officinalis , possibly associated with certain genes were identified, laying a foundation for future research into the genetic diversity and medicinal value of C. officinalis .