The rate and significance of type 1/type 2 serum amyloid A protein gene polymorphisms in patients with ankylosing spondylitis and amyloidosis

• Published in: Amyloid Vol. 22; no. 3; pp. 207 - 208
• Main Authors: Yildirim Cetin, Gozde, Ganiyusufoglu, Eda, Solmaz, Dilek, Cagatay, Yonca, Yılmaz Oner, Sibel, Erer, Burak, Sagliker, Hasan Sabit, Avci, Ali Berkant, Akar, Servet, Pamuk, Omer Nuri, Kılınc, Metin, Kasifoglu, Timucin, Direskeneli, Haner, Gul, Ahmet, Sayarlioglu, Mehmet
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 03.07.2015
• Subjects: Adult; Alleles; Amyloidosis; Amyloidosis - complications; Amyloidosis - genetics; Amyloidosis - pathology; ankylosing spondylitis; Creatinine - blood; Cytoskeletal Proteins - genetics; Familial Mediterranean Fever - complications; Familial Mediterranean Fever - genetics; Familial Mediterranean Fever - pathology; Female; Gene Expression; Gene Frequency; Humans; Male; Middle Aged; Mutation; Polymorphism, Single Nucleotide; Proteinuria - pathology; Proteinuria - urine; Pyrin; Serum Amyloid A Protein - genetics; Spondylitis, Ankylosing - complications; Spondylitis, Ankylosing - genetics; Spondylitis, Ankylosing - pathology; type 1/type 2 serum amyloid A protein genes; Amyloidosis; type 1/type 2 serum amyloid A protein genes; ankylosing spondylitis
• ISSN: 1350-6129; 1744-2818
• DOI: 10.3109/13506129.2015.1068751

A relationship between the presence of amyloidosis and SAA1 genotype has been shown in recent studies of (principally) familial Mediterranean fever patients. We found that the SAA1 rs12218 polymorphism was significantly more prevalent in ankylosing spondylitis patients with amyloidosis.