Magnetic resonance velocity mapping of 3D cerebrospinal fluid flow dynamics in hydrocephalus: preliminary results

• Published in: European radiology Vol. 22; no. 1; pp. 232 - 242
• Main Authors: Stadlbauer, Andreas, Salomonowitz, Erich, Brenneis, Christian, Ungersböck, Karl, van der Riet, Wilma, Buchfelder, Michael, Ganslandt, Oliver
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.01.2012; Springer Nature B.V
• Subjects: Adult; Aged; Aged, 80 and over; Cerebral Aqueduct - pathology; Cerebral Aqueduct - physiopathology; Cerebrospinal fluid; Cerebrospinal Fluid Pressure; Diagnostic Radiology; Female; Follow-Up Studies; Humans; Hydrocephalus; Hydrocephalus - cerebrospinal fluid; Hydrocephalus - diagnosis; Hydrocephalus - physiopathology; Imaging; Imaging, Three-Dimensional; Internal Medicine; Interventional Radiology; Intracranial Pressure; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Medicine; Medicine & Public Health; Middle Aged; Neuro; Neuroradiology; Neurosurgery; Patients; Prospective Studies; Radiology; Ultrasound; Velocity; Austria; Magnetic resonance velocity mapping; Flow dynamics; Cerebrospinal fluid; Hydrocephalus; Ventricular system
• ISSN: 0938-7994; 1432-1084
• DOI: 10.1007/s00330-011-2247-7

Objectives To investigate the detectability of CSF flow alterations in the ventricular system of patients with hydrocephalus using time-resolved 3D MR velocity mapping. Methods MR velocity mapping was performed in 21 consecutive hydrocephalus patients and 21 age-matched volunteers using a 3D phase-contrast (PC) sequence. Velocity vectors and particle path lines were calculated for visualisation of flow dynamics. CSF flow was classified as “hypomotile flow” if it showed attenuated dynamics and as “hypermotile flow” if it showed increased dynamics compared with volunteers. Diagnostic efficacy was compared with routine 2D cine PC-MRI. Results Seven patients showed hypomotile CSF flow: six had non-communicating hydrocephalus due to aqueductal stenosis. One showed oscillating flow between the lateral ventricles after craniotomy for intracranial haemorrhage. Seven patients showed normal flow: six had hydrocephalus ex vacuo due to brain atrophy. One patient who underwent ventriculostomy 10 years ago showed a flow path through the opening. Seven patients showed hypermotile flow: three had normal pressure hydrocephalus, three had dementia, and in one the diagnosis remained unclear. The diagnostic efficacy of velocity mapping was significantly higher except for that of aqueductal stenosis. Conclusions Our approach may be useful for diagnosis, therapy planning, and follow-up of different kinds of hydrocephalus. Key Points • Velocity-mapping provides additional information about CSF flow compared to 2D phase-contrast MRI • Ventricular CSF flow of hydrocephalus patients and volunteers shows complex 3D dynamics • This technique may be useful for the management of patients with hydrocephalus • The pathophysiological basis of CSF flow dysfunction may be better understood