Hyperthermia by a nitinol stent in an alternating magnetic field: Safety and feasibility in rabbit esophageal cancer
Hyperthermia by heating in-stent is a potentially new method to treat esophageal cancer. This study assessed the safety of heating the rabbit esophagus with a nitinol stent in an alternating magnetic field (AMF) and investigated whether this method offers a therapeutic option for esophageal cancer....
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Published in | Progress in natural science Vol. 19; no. 12; pp. 1713 - 1719 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Ltd
10.12.2009
Department of Oncology,Xiangya Hospital of Central South University,Changsha 410008,China Institute of Medical Physics and Engineering,Department of Engineering Physics,TsingHua University,Beijing 100084,China%The People Hospital of Zhangqiu City,Jinan 250200,China%Clinical Institute of Science,China-Japan Friendship Hospital,Beijing 100029,China%Department of Oncology,Xiangya Hospital of Central South University,Changsha 410008,China%Institute of Medical Physics and Engineering,Department of Engineering Physics,TsingHua University,Beijing 100084,China |
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Summary: | Hyperthermia by heating in-stent is a potentially new method to treat esophageal cancer. This study assessed the safety of heating the rabbit esophagus with a nitinol stent in an alternating magnetic field (AMF) and investigated whether this method offers a therapeutic option for esophageal cancer. Nitinol stents were placed in the cervical esophagi of healthy rabbits, which were heated in an AMF for different times at 43, 46 and 50 ℃. The esophagi were histologically examined after a week to observe whether there was transmural necroses. Then esophageal cancer of rabbit placed nitinol stents were heated in an AMF at 46 ℃ for 10 min. Stents were heated to a target temperature within 5 min. The highest tolerated temperature and time for the healthy rabbit esophagus was at 46 ℃ for 10 min. Tumor growth was delayed by heating and it was statistically significant. Heating the rabbit esophageal wall at 46 ℃ for 10 min proves to be safe and effective in delaying tumor growth. |
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Bibliography: | TG139.6 Hyperthermia; Nitinol stent; Alternating magnetic field; Rabbit; Esophageal tumor Esophageal tumor Alternating magnetic field Rabbit S858.974 Hyperthermia Nitinol stent 11-3853/N ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 1002-0071 |
DOI: | 10.1016/j.pnsc.2009.07.013 |