Hyperthermia by a nitinol stent in an alternating magnetic field: Safety and feasibility in rabbit esophageal cancer

Hyperthermia by heating in-stent is a potentially new method to treat esophageal cancer. This study assessed the safety of heating the rabbit esophagus with a nitinol stent in an alternating magnetic field (AMF) and investigated whether this method offers a therapeutic option for esophageal cancer....

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Published inProgress in natural science Vol. 19; no. 12; pp. 1713 - 1719
Main Authors Zhou, Jumei, Li, Ning, Xia, Qisheng, Du, Lehui, Wang, Xiaowen, Zhao, Linyun, Wang, Xufei, Tang, Jintian
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 10.12.2009
Department of Oncology,Xiangya Hospital of Central South University,Changsha 410008,China
Institute of Medical Physics and Engineering,Department of Engineering Physics,TsingHua University,Beijing 100084,China%The People Hospital of Zhangqiu City,Jinan 250200,China%Clinical Institute of Science,China-Japan Friendship Hospital,Beijing 100029,China%Department of Oncology,Xiangya Hospital of Central South University,Changsha 410008,China%Institute of Medical Physics and Engineering,Department of Engineering Physics,TsingHua University,Beijing 100084,China
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Summary:Hyperthermia by heating in-stent is a potentially new method to treat esophageal cancer. This study assessed the safety of heating the rabbit esophagus with a nitinol stent in an alternating magnetic field (AMF) and investigated whether this method offers a therapeutic option for esophageal cancer. Nitinol stents were placed in the cervical esophagi of healthy rabbits, which were heated in an AMF for different times at 43, 46 and 50 ℃. The esophagi were histologically examined after a week to observe whether there was transmural necroses. Then esophageal cancer of rabbit placed nitinol stents were heated in an AMF at 46 ℃ for 10 min. Stents were heated to a target temperature within 5 min. The highest tolerated temperature and time for the healthy rabbit esophagus was at 46 ℃ for 10 min. Tumor growth was delayed by heating and it was statistically significant. Heating the rabbit esophageal wall at 46 ℃ for 10 min proves to be safe and effective in delaying tumor growth.
Bibliography:TG139.6
Hyperthermia; Nitinol stent; Alternating magnetic field; Rabbit; Esophageal tumor
Esophageal tumor
Alternating magnetic field
Rabbit
S858.974
Hyperthermia
Nitinol stent
11-3853/N
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1002-0071
DOI:10.1016/j.pnsc.2009.07.013