CETP and APOA2 polymorphisms are associated with weight loss and healthy eating behavior changes in response to digital lifestyle modifications

• Published in: Scientific reports Vol. 13; no. 1; p. 21615
• Main Authors: Kim, Meelim, Lee, Seolha, Cho, Eun, Hong, Kyung-Won, You, So-Jin, Choi, Hyung Jin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.12.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/208/727; 692/700/2817; 692/700/565; Apolipoprotein A-II; Body Mass Index; Body weight loss; Cholesterol Ester Transfer Proteins - genetics; Cognitive ability; Diet; Diet, Healthy; Eating behavior; Emotional behavior; Feeding Behavior; Gene polymorphism; Genotype; Genotypes; Health care; Humanities and Social Sciences; Humans; Life Style; Lifestyles; multidisciplinary; NCT; NCT03465306; Obesity; Obesity - genetics; Phenotypes; Polymorphism, Single Nucleotide; Precision medicine; Science; Science (multidisciplinary); Single-nucleotide polymorphism; Weight control; Weight Loss - genetics
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-48823-w

Response to digital healthcare lifestyle modifications is highly divergent. This study aimed to examine the association between single nucleotide polymorphism (SNP) genotypes and clinical efficacy of a digital healthcare lifestyle modification. We genotyped 97 obesity-related SNPs from 45 participants aged 18–39 years, who underwent lifestyle modification via digital cognitive behavioral therapy for obesity for 8 weeks. Anthropometric, eating behavior phenotypes, and psychological measures were analyzed before and after the intervention to identify their clinical efficacy. CETP (rs9939224) SNP significantly predict “super-responders” with greater body mass index (BMI) reduction (p = 0.028; GG − 2.91%, GT − 9.94%), while APOA2 (rs5082) appeared to have some potential for predicting “poor-responders” with lower BMI reduction (p = 0.005; AA − 6.17%, AG + 2.05%, and GG + 5.11%). These SNPs was also associated with significant differences in eating behavior changes, healthy diet proportions, health diet diversity, emotional and restrained eating behavior changes. Furthermore, classification using gene–gene interactions between rs9939224 and rs5082 significantly predicted the best response, with a greater decrease in BMI (p = 0.038; − 11.45% for the best response group ( CEPT GT/TT × APOA2 AA) vs. + 2.62% for the worst response group ( CEPT GG × APOA2 AG/GG)). CETP and APOA2 SNPs can be used as candidate markers to predict the efficacy of digital healthcare lifestyle modifications based on genotype-based precision medicine. Trial registration: NCT03465306, ClinicalTrials.gov. Registered March, 2018.