Brønsted acid-mediated reactions of ynamides

Over the past two decades, the development and application of ynamide chemistry have received more and more attention. Ynamides have proven to be versatile reagents for organic synthesis, and have been widely applied to the rapid assembly of a diverse range of structurally complex N-containing molec...

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Published inChemical Society reviews Vol. 49; no. 24; pp. 8897 - 899
Main Authors Chen, Yang-Bo, Qian, Peng-Cheng, Ye, Long-Wu
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 21.12.2020
Subjects
Chemical reactions
Cycloaddition
cycloaddition reactions
heterocyclic nitrogen compounds
oxygen
Reagents
society
synthesis
Transition metals
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Summary:Over the past two decades, the development and application of ynamide chemistry have received more and more attention. Ynamides have proven to be versatile reagents for organic synthesis, and have been widely applied to the rapid assembly of a diverse range of structurally complex N-containing molecules, especially the valuable N-heterocycles. In comparison with the well-established transition metal-catalyzed reactions of ynamides, metal-free ynamide transformations have relatively seldom been exploited. Recently, Brønsted acid-mediated reactions of ynamides represent significant advances in ynamide chemistry. This review summarizes the latest trends and developments of Brønsted acid-mediated reactions of ynamides, including cycloaddition, cyclization, intramolecular alkoxylation-initiated rearrangement, oxygen atom transfer reactions and hydro-heteroatom addition reactions. This review summarizes the latest trends and developments of Brønsted acid-mediated reactions of ynamides, including cycloaddition, cyclization and so on.
Bibliography:Long-Wu Ye was born in 1981 in Wenzhou, Zhejiang province of China. He received his BSc in chemistry from Zhejiang University (2003). He then obtained his PhD in 2008 from Shanghai Institute of Organic Chemistry, CAS, under the guidance of Prof. Yong Tang. After postdoctoral studies with Prof. Cheng Liu and Subhash Sinha at The Scripps Research Institute and with Prof. Liming Zhang at the University of California at Santa Barbara, he joined Xiamen University in 2011 as an associate Professor. He was promoted to a full Professor in 2012. His current research interests include the development of ynamide chemistry and their use in bioactive molecule and natural product synthesis.
Peng-Cheng Qian was born in 1978 in Wenzhou, Zhejiang province of China. He obtained his PhD in 2015 from Hu'nan University, under the guidance of Prof. Jin-Heng Li. As a visiting scholar he studied with Prof. Liming Zhang at the University of California at Santa Barbara from 2017 to 2018. He joined Wenzhou University in 2002 and now is an associate Professor. His current research interests include the development of new transition metal-catalyzed reactions and ligand synthesis.
Yang-Bo Chen was born in 1995 in Shaoxing, Zhejiang province of China. He earned his BSc in Chemistry from Nanjing University of Science and Technology in 2018. He is currently a third-year graduate student in the group of Prof. Long-Wu Ye at Xiamen University.
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ISSN:0306-0012
1460-4744
1460-4744
DOI:10.1039/d0cs00474j