Defining Dysbiosis in Inflammatory Bowel Disease

In this issue of Immunity, Britton et al. (2019) demonstrate that the colonization of germ-free mice with microbiotas from inflammatory bowel disease patients induces an altered ratio of RORγt+ regulatory T cells to T(h17) effector cells and recapitulates human disease severity in colitis-susceptibl...

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Bibliographic Details
Published inImmunity (Cambridge, Mass.) Vol. 50; no. 1; pp. 8 - 10
Main Authors de Jong, Renske J., Ohnmacht, Caspar
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 15.01.2019
Elsevier Limited
Subjects
Colitis
Colonization
Dendritic cells
Dysbacteriosis
Effector cells
Feces
Germfree
Homeostasis
Immunity
Immunoregulation
Inflammation
Inflammatory bowel disease
Inflammatory bowel diseases
Intestine
Lymphocytes
Lymphocytes T
Mice
Microbiota
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Summary:In this issue of Immunity, Britton et al. (2019) demonstrate that the colonization of germ-free mice with microbiotas from inflammatory bowel disease patients induces an altered ratio of RORγt+ regulatory T cells to T(h17) effector cells and recapitulates human disease severity in colitis-susceptible mice. In this issue of Immunity, Britton et al. (2019) demonstrate that the colonization of germ-free mice with microbiotas from inflammatory bowel disease patients induces an altered ratio of RORγt+ regulatory T cells to T(h17) effector cells and recapitulates human disease severity in colitis-susceptible mice.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2018.12.028