Shedding light on curcumin stability

The stability of molecular curcumin (purcumin, 1a) in solution is strongly light-dependent. Under laboratory artificial light, a relative stability is observed only at neutral pH, while more intense light and/or solar light can trigger degradation via a combination of hydrolytic and oxidative fragme...

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Bibliographic Details
Published inFitoterapia Vol. 156; p. 105084
Main Authors Appendino, Giovanni, Allegrini, Pietro, de Combarieu, Eric, Novicelli, Federico, Ramaschi, Giuseppe, Sardone, Nicola
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.01.2022
Elsevier Science Ltd
Subjects
Bicyclopentandione
Biological activity
Chromatography, High Pressure Liquid
Curcumin
Curcumin - chemistry
Curcumin - metabolism
Degradation
Drug Stability
Ferulic acid
Hydrogen-Ion Concentration
Irradiation
Light
Light irradiation
Photodegradation
Radiation
Solutions
Stability
Turmeric
Turmeric
Photodegradation
Curcumin
Bicyclopentandione
Ferulic acid
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Summary:The stability of molecular curcumin (purcumin, 1a) in solution is strongly light-dependent. Under laboratory artificial light, a relative stability is observed only at neutral pH, while more intense light and/or solar light can trigger degradation via a combination of hydrolytic and oxidative fragmentation of the heptadiendione moiety. Minor curcuminoids in commercial curcumin (purcuminoids) can improve the stability of molecular curcumin, but only under conditions of low irradiation. While confirming earlier observations alerting to the instability of purcumin, our results provide new rationales for unexplained differences between previous studies, question the biological relevance of a non-enzymatic degradation for the bioactivity profiles that have been reported for purcumin, and highlight the need of a better characterization of the degradation of purcuminoids under visible light irradiation. [Display omitted]
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2021.105084