Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors
C. E. Stewart and P. Rotwein Department of Biochemistry, Washington University School of Medicine, Saint Louis, Missouri, USA. The insulin-like growth factors (IGFs), IGF-I and IGF-II, comprise a conserved pair of secreted proteins with diverse effects on growth, development, and metabolism. Insulin...
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Published in | Physiological reviews Vol. 76; no. 4; pp. 1005 - 1026 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
Am Physiological Soc
01.10.1996
American Physiological Society |
Subjects | |
Online Access | Get full text |
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Summary: | C. E. Stewart and P. Rotwein
Department of Biochemistry, Washington University School of Medicine, Saint Louis, Missouri, USA.
The insulin-like growth factors (IGFs), IGF-I and IGF-II, comprise a
conserved pair of secreted proteins with diverse effects on growth,
development, and metabolism. Insulin-like growth factor action is initiated
upon binding to cell-surface receptors and is modulated through
interactions with secreted IGF binding proteins (IGFBPs). The last decade
has seen an explosion of new information about the physiological roles of
the IGFs. In this review, we critically examine this information from
biochemical, cell biological, and molecular genetic perspectives. We
discuss the structures and functions of the two IGF receptors, outline the
actions of the six IGFBPs, and summarize and interpret recent studies
highlighting essential roles for components of the IGF system in the growth
and development of the embryo and fetus, in tissue differentiation, in cell
survival and proliferation, and in cancer. These results are discussed in
the context of new opportunities for understanding the mechanisms of IGF
action in multiple biological processes. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0031-9333 1522-1210 |
DOI: | 10.1152/physrev.1996.76.4.1005 |