The bioactivity of novel furanoterpenoids isolated from Siphonochilus aethiopicus
This study investigated the medicinal plant Siphonochilus aethiopicus (Zingiberaceae) for antiplasmodial activity. The ethyl acetate extract of Siphonochilus aethiopicus rhizomes was fractionated using solid phase extraction (SPE) and purified by high performance liquid chromatography. Structure elu...
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Published in | Journal of ethnopharmacology Vol. 121; no. 1; pp. 92 - 97 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Shannon
Elsevier Ireland Ltd
12.01.2009
Amsterdam; New York: Elsevier Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | This study investigated the medicinal plant
Siphonochilus aethiopicus (Zingiberaceae) for antiplasmodial activity.
The ethyl acetate extract of
Siphonochilus aethiopicus rhizomes was fractionated using solid phase extraction (SPE) and purified by high performance liquid chromatography. Structure elucidation was performed with nuclear magnetic resonance and mass spectrometry. The
in vitro cytotoxicity and antiplasmodial activity was determined.
In vivo schizontocidal activity was performed in a malaria mouse-model. Additional
in vitro testing was done against
Staphylococcus aureus,
Klebsiella pneumoniae and
Mycobacterium tuberculosis.
The ethyl acetate extract showed
in vitro activity against the chloroquine-sensitive (CQS) and chloroquine-resistant (CQR) strains of
Plasmodium falciparum with IC
50-values of 2.9
μg/ml and 1.4
μg/ml, respectively. Bioassay-guided fractionation led to the isolation of three novel furanoterpenoids with moderate
in vitro antiplasmodial activity. The crude extract showed very good
in vivo activity. The compounds and crude extract were more active against the CQR strain than the CQS strain of
Plasmodium falciparum. The SPE fractions were more active than the isolated compounds. The compounds did not show good activity against the micro-organisms tested. No
in vitro cytotoxicity was observed.
This study provides evidence of antiplasmodial compounds present in
Siphonochilus aethiopicus. |
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Bibliography: | http://dx.doi.org/10.1016/j.jep.2008.10.007 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0378-8741 1872-7573 |
DOI: | 10.1016/j.jep.2008.10.007 |