18F-FDG PET/CT Evaluation of Thymomas: a Pictorial Review
The World Health Organization classification divides thymomas according to morphology, epithelial component, and cell atypia. They are grouped into 3 large subgroups: low-risk thymomas (types A, AB, and B1), high-risk thymomas (types B2 and B3), and thymic carcinomas. Tumor subtype represents an ind...
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Published in | Nuclear medicine and molecular imaging Vol. 55; no. 4; pp. 186 - 193 |
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Main Authors | , |
Format | Journal Article |
Language | English |
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01.08.2021
Springer Nature B.V 대한핵의학회 |
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Abstract | The World Health Organization classification divides thymomas according to morphology, epithelial component, and cell atypia. They are grouped into 3 large subgroups: low-risk thymomas (types A, AB, and B1), high-risk thymomas (types B2 and B3), and thymic carcinomas. Tumor subtype represents an independent prognostic factor, which determines therapeutic decision. All thymomas show some degree of
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F-FDG uptake, which tends to increase with the grade of malignancy; this is related to glucose transporter 1 (GLUT1) expression. This review collects all types of thymomas with illustrative images and provides a guide to get familiar with histological characteristics of the lesions and have them in mind because, even imaging findings can overlap among subtypes, certain characteristics can be combined to make an accurate diagnosis based on
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F-FDG PET-CT findings. |
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AbstractList | The World Health Organization classification divides thymomas according to morphology, epithelial component, and cell atypia. They are grouped into 3 large subgroups: low-risk thymomas (types A, AB, and B1), high-risk thymomas (types B2 and B3), and thymic carcinomas. Tumor subtype represents an independent prognostic factor, which determines therapeutic decision. All thymomas show some degree of
18
F-FDG uptake, which tends to increase with the grade of malignancy; this is related to glucose transporter 1 (GLUT1) expression. This review collects all types of thymomas with illustrative images and provides a guide to get familiar with histological characteristics of the lesions and have them in mind because, even imaging findings can overlap among subtypes, certain characteristics can be combined to make an accurate diagnosis based on
18
F-FDG PET-CT findings. The World Health Organization classification divides thymomas according to morphology, epithelial component, and cell atypia. They are grouped into 3 large subgroups: low-risk thymomas (types A, AB, and B1), high-risk thymomas (types B2 and B3), and thymic carcinomas. Tumor subtype represents an independent prognostic factor, which determines therapeutic decision. All thymomas show some degree of 18F-FDG uptake, which tends to increase with the grade of malignancy; this is related to glucose transporter 1 (GLUT1) expression. This review collects all types of thymomas with illustrative images and provides a guide to get familiar with histological characteristics of the lesions and have them in mind because, even imaging findings can overlap among subtypes, certain characteristics can be combined to make an accurate diagnosis based on 18F-FDG PET-CT findings. The World Health Organization classification divides thymomas according to morphology, epithelial component, and cell atypia. They are grouped into 3 large subgroups: low-risk thymomas (types A, AB, and B1), high-risk thymomas (types B2 and B3), and thymic carcinomas. Tumor subtype represents an independent prognostic factor, which determines therapeutic decision. All thymomas show some degree of 18F-FDG uptake, which tends to increase with the grade of malignancy; this is related to glucose transporter 1 (GLUT1) expression. This review collects all types of thymomas with illustrative images and provides a guide to get familiar with histological characteristics of the lesions and have them in mind because, even imaging findings can overlap among subtypes, certain characteristics can be combined to make an accurate diagnosis based on 18F-FDG PET-CT findings. KCI Citation Count: 0 |
Author | Murad, Vanessa Kim, E. Edmund |
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Cites_doi | 10.1258/ar.2012.120536 10.2147/CMAR.S146522 10.1016/j.lungcan.2008.01.003 10.1097/JTO.0b013e3182835549 |
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Keywords | Thymomas Nuclear medicine Oncology Thymic epithelial tumors F-FDG PET-CT |
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References | EndoMNakagawaKOhdeYOkumuraTKondoHIgawaSUtility of 18FDG-PET for differentiating the grade of malignancy in thymic epithelial tumorsLung Cancer20086135035510.1016/j.lungcan.2008.01.003 NakagawaKTakahashiSEndoMOhdeYKuriharaHTerauchiTCan 18F-FDG PET predict the grade of malignancy in thymic epithelial tumors? An evaluation of only resected tumorsCancer Manag Res2017976176810.2147/CMAR.S146522 SungYMLeeKSKimB-TChoiJYShimYMYiCA18F-FDG PET/CT of thymic epithelial tumors: usefulness for distinguishing and staging tumor subgroupsJ Nucl Med2006471628163417015898 SharmaPSinghalAKumarABalCMalhotraAKumarREvaluation of thymic tumors with 18F-FDG PET-CT: a pictorial reviewActa Radiol201354142110.1258/ar.2012.120536 BenvenisteMFMoranCAMawlawiOFDG PET-CT aids in the preoperative assessment of patients with newly diagnosed thymic epithelial malignanciesJ Thorac Oncol20138450251010.1097/JTO.0b013e3182835549 Rouse RV (2017/09/07) Stanford Medicine Surgical Pathology Criteria. Retrieved from: http://surgpathcriteria.stanford.edu/thymus/thymoma/. Accessed 20 Jan 2021 SasakiMKuwabaraYIchiyaYDifferential diagnosis of thymic tumors using a combination of 11C-methionine PET and FDG PETJ Nucl Med199940159516011:STN:280:DyaK1MvkvFSjtQ%3D%3D10520697 EndoaMNakagawabKOhdebYOkumurabTKondobHIgawacSUtility of 18FDG-PET for differentiating the grade of malignancy in thymic epithelial tumorsLung Cancer20086135035510.1016/j.lungcan.2008.01.003 M Endo (705_CR6) 2008; 61 P Sharma (705_CR2) 2013; 54 K Nakagawa (705_CR7) 2017; 9 705_CR1 M Endoa (705_CR3) 2008; 61 M Sasaki (705_CR4) 1999; 40 MF Benveniste (705_CR8) 2013; 8 YM Sung (705_CR5) 2006; 47 |
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Title | 18F-FDG PET/CT Evaluation of Thymomas: a Pictorial Review |
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