Induction of SCEs by some pyrrolizidine alkaloids in V79 Chinese hamster cells co-cultured with chick embryo hepatocytes

Genotoxicity of heliotrine, monocrotaline, seneciphylline and senkirkine was studied with the sister-chromatid exchange assay in V79 Chinese hamster cells. Exposure to these pyrrolizidine alkaloids, in the presence of co-cultured primary chick embryo hepatocytes, resulted in a high induction of SCEs...

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Bibliographic Details
Published inMutation research Vol. 142; no. 4; pp. 209 - 212
Main Authors Bruggeman, I.M., van der Hoeven, J.C.M.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.01.1985
Subjects
Animals
Biotransformation
Cell Line
Cell Survival - drug effects
Chick Embryo
Cricetinae
Cricetulus
Liver - cytology
Liver - metabolism
Male
Microsomes, Liver - metabolism
Mutagens
Pyrrolizidine Alkaloids - metabolism
Pyrrolizidine Alkaloids - toxicity
Rats
Rats, Inbred Strains
Sister Chromatid Exchange - drug effects
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Summary:Genotoxicity of heliotrine, monocrotaline, seneciphylline and senkirkine was studied with the sister-chromatid exchange assay in V79 Chinese hamster cells. Exposure to these pyrrolizidine alkaloids, in the presence of co-cultured primary chick embryo hepatocytes, resulted in a high induction of SCEs. It was also shown for heliotrine that co-cultivation with chick embryo hepatocytes resulted in a much higher response than addition of activated rat-liver homogenate to the test medium.
ISSN:0165-7992
0027-5107
DOI:10.1016/0165-7992(85)90025-9