The origins and evolution of the p53 family of genes

A common ancestor to the three p53 family members of human genes p53, p63, and p73 is first detected in the evolution of modern-day sea anemones, in which both structurally and functionally it acts to protect the germ line from genomic instabilities in response to stresses. This p63/p73 common ances...

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Published inCold Spring Harbor perspectives in biology Vol. 2; no. 6; p. a001198
Main Authors Belyi, Vladimir A, Ak, Prashanth, Markert, Elke, Wang, Haijian, Hu, Wenwei, Puzio-Kuter, Anna, Levine, Arnold J
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 01.06.2010
Subjects
Animals
Biological Evolution
Gene Expression Regulation - physiology
Humans
Multigene Family
Protein Structure, Tertiary
Tumor Suppressor Proteins - genetics
Tumor Suppressor Proteins - metabolism
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Summary:A common ancestor to the three p53 family members of human genes p53, p63, and p73 is first detected in the evolution of modern-day sea anemones, in which both structurally and functionally it acts to protect the germ line from genomic instabilities in response to stresses. This p63/p73 common ancestor gene is found in almost all invertebrates and first duplicates to produce a p53 gene and a p63/p73 ancestor in cartilaginous fish. Bony fish contain all three genes, p53, p63, and p73, and the functions of these three transcription factors diversify in the higher vertebrates. Thus, this gene family has preserved its structural features and functional activities for over one billion years of evolution.
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ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a001198