Abnormal vitamin D and lipid profile in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients

• Published in: Molecular biology reports Vol. 47; no. 1; pp. 631 - 637
• Main Authors: Derakhshan, Reza, Mirhosseini, Ali, Ahmadi Ghezeldasht, Sanaz, Jahantigh, Hamid Reza, Mohareri, Mehran, Boostani, Reza, Derakhshan, Mohammad, Rezaee, Seyed Abdolrahim
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.01.2020; Springer Nature B.V
• Subjects: Adult; Animal Anatomy; Animal Biochemistry; Biomedical and Life Sciences; Case-Control Studies; Central nervous system diseases; Cholesterol; Cholesterol - blood; Female; High density lipoprotein; Histology; Human T-lymphotropic virus 1; Humans; Iran; Life Sciences; lipid composition; Lipids; Low density lipoprotein; Lymphocytes; Male; Middle Aged; molecular biology; Morphology; Multiple sclerosis; Neurodegenerative diseases; Original Article; Paraparesis, Tropical Spastic - blood; Paraparesis, Tropical Spastic - epidemiology; Paraparesis, Tropical Spastic - virology; sclerosis; Spastic paraparesis; Spasticity; Spinal cord; triacylglycerols; Triglycerides; Triglycerides - blood; Tropical spastic paraparesis; Viral Load; Vitamin D; Vitamin D - blood; Iran; HDL; Vitamin D; LDL; Lipid profile; HAM/TSP; HTLV-1; Triglycerides; Cholesterol
• ISSN: 0301-4851; 1573-4978; 1573-4978
• DOI: 10.1007/s11033-019-05171-1

The HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurodegenerative disease of host-HTLV-1 interactions. In many virus-associated diseases and multiple sclerosis, the importance of vitamin-D and lipid profile has been demonstrated, thus similarly, their impacts were evaluated in HAM/TSP patients, in this study. Vitamin D and lipid profile were assessed in 120 healthy subjects (HSs), along with a proviral load (PVL) in 91 HAM/TSPs and 169 HTLV-1 carriers (ACs). The mean level of triglyceride and LDL in the HAM/TSPs were higher than HSs ( P  = 0.008 and 0.008, respectively), but no significant difference has been found between ACs and HSs. However, the level of HDL and vitamin-D in the HAM/TSP subjects were lower than HSs ( P  = 0.01 and P  = 0.006, respectively). In HTLV-1 infected subjects, PVL was statistically associated with cholesterol (R = 0.24, P  = 0.038), triglycerides (R = 0.26, P  = 0.01) and HDL (R = 0.28, P  = 0.001), and in HAM/TSPs there was a strong association between the severity of the disease, as determined by the OMDS and cholesterol ( P  = 0.01). Furthermore, in the HAM/TSPs, positive correlations between vitamin-D and age (R = 0.23, P  = 0.028) and triglycerides (R = 0.38, P  = 0.001) were found, also a significant correlation between PVL and LDL (R = 0.21, P  = 0.001) and a weak correlation between PVL and OMDS (R = 0.4, P  = 0.07) were noted. However, there was no correlation between PVL and urinary disturbance. Furthermore, PVL range of more than 600 copies/10 4 lymphocytes had a strong correlation with OMDS ( P  = 0.05), but not with urinary disturbance. It’s more likely that HAM/TSP patients have an imbalanced lipid profile and low levels of vitamin D and may represent a potentially useful target for intervention in HTLV-1 associated diseases.