Hepatitis from Greater celandine ( Chelidonium majus L.): Review of literature and report of a new case
Folk medicine is a rich source of useful therapeutic tools. Nevertheless, use of medicinal plants can have unwanted, negative effects. By means of the description of an adverse reaction to a herbal remedy, we highlight the need for better efficacy-toxicity studies on these products. To report a case...
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Published in | Journal of ethnopharmacology Vol. 124; no. 2; pp. 328 - 332 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Shannon
Elsevier Ireland Ltd
15.07.2009
Amsterdam; New York: Elsevier Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Folk medicine is a rich source of useful therapeutic tools. Nevertheless, use of medicinal plants can have unwanted, negative effects. By means of the description of an adverse reaction to a herbal remedy, we highlight the need for better efficacy-toxicity studies on these products.
To report a case of possible
Chelidonium majus L. (Greater celandine)-induced hepatitis and evaluate the past published cases.
We outlined the main features of hepatitis associated with use of
Chelidonium majus by providing a review of cases reported and analysing in detail a new one.
Several cases of acute hepatitis related to Greater celandine consumption were found in the literature. The assessment for causality using Naranjo probability scale showed a probable relationship between the liver injury and the consumption of
Chelidonium majus in the case we described.
Our case, along with the other ones reported in the literature, increases the concern about the safety of oral use of
Chelidonium majus. Plants used in traditional medicine are not necessarily harmless. Customers and prescribers should be aware of this, especially when a herbal drug is used with therapeutic purposes in absence of reliable studies of clinical efficacy and benefit-risk assessment. |
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Bibliography: | http://dx.doi.org/10.1016/j.jep.2009.04.036 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0378-8741 1872-7573 |
DOI: | 10.1016/j.jep.2009.04.036 |