Salvage of renal allograft function and lower extremity venous patency with thrombolytic therapy: Case report and review of the literature

Five months after a cadaveric renal transplant a 69-year-old man was admitted with caval, iliac, and renal allograft vein thrombosis that occurred in the setting of a previously placed caval filter. The patient's urine output and renal function deteriorated rapidly. Thrombolytic therapy with ur...

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Bibliographic Details
Published inJournal of vascular surgery Vol. 21; no. 4; pp. 691 - 696
Main Authors Killewich, Lois A., Pais, S.Osher, Sandager, Gail, Flinn, William R., Bartlett, Stephen T.
Format Journal Article
LanguageEnglish
Published New York, NY Mosby, Inc 01.04.1995
Elsevier
Subjects
Aged
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Femoral Vein - pathology
Follow-Up Studies
Graft Occlusion, Vascular - drug therapy
Graft Survival
Humans
Iliac Vein - pathology
Kidney Transplantation - physiology
Male
Medical sciences
Pharmacology. Drug treatments
Renal Veins - pathology
Thrombolytic Therapy
Thrombosis - drug therapy
Transplantation, Homologous
Urokinase-Type Plasminogen Activator - therapeutic use
Vascular Patency
Vena Cava Filters
Vena Cava, Inferior - pathology
Human
u-Plasminogen activator
Serine endopeptidases
Enzyme
Cardiovascular disease
Transplantation
Homotransplantation
Thrombosis
Kidney
Venous disease
Vascular disease
Case study
Chemotherapy
Treatment
Urinary system
Surgery
Hydrolases
Complication
Proteinases
Iliac vein
Fibrinolytic
Vena cava
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Summary:Five months after a cadaveric renal transplant a 69-year-old man was admitted with caval, iliac, and renal allograft vein thrombosis that occurred in the setting of a previously placed caval filter. The patient's urine output and renal function deteriorated rapidly. Thrombolytic therapy with urokinase was begun, and lysis of the thrombus occurred in 72 hours. The patient's renal function returned to baseline, and the transplant was salvaged. Moreover lower extremity venous patency and valvular function were maintained. We report the case and review the literature on thrombolytic therapy for renal allograft vein and lower extremity deep venous thrombosis. (J V ASC S URG 1995;21:691-6.)
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Review-3
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ObjectType-Case Study-5
ObjectType-Feature-1
ObjectType-Report-4
ISSN:0741-5214
1097-6809
DOI:10.1016/S0741-5214(95)70200-8