Effects of Humoral Immunity and Calreticulin Overexpression on Postoperative Course in Breast Cancer

The aim was to investigate whether the humoral immunity and overexpression of calreticulin in tumor tissue determined before surgery, correlate with incidence of metastases in breast cancer patients within two years after operation. Before operation, their humoral immunity and overexpression of cale...

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Published inPathology oncology research Vol. 15; no. 1; pp. 89 - 90
Main Authors Eric, Aleksandra, Juranic, Zorica, Milovanovic, Zorka, Markovic, Ivan, Inic, Momcilo, Stanojevic-bakic, Nevenka, Vojinovic-golubovic, Vesna
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.03.2009
Springer Nature B.V
Subjects
Antibody Formation - physiology
Biomarkers, Tumor - metabolism
Biomedical and Life Sciences
Biomedicine
Breast cancer
Breast Neoplasms - immunology
Breast Neoplasms - metabolism
Breast Neoplasms - surgery
Brief Communication
Calreticulin - metabolism
Cancer Research
Female
Humans
Immunoglobulin A - immunology
Immunoglobulin G - immunology
Immunoglobulin M - immunology
Immunology
Lymphatic Metastasis
Oncology
Pathology
Receptor, ErbB-2 - metabolism
Tumors
Calreticulin
Breast cancer
Surgery
Humoral immunity
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Summary:The aim was to investigate whether the humoral immunity and overexpression of calreticulin in tumor tissue determined before surgery, correlate with incidence of metastases in breast cancer patients within two years after operation. Before operation, their humoral immunity and overexpression of caleticulin and Her-2/neu in tumor tissue were analyzed by immunohystochemistry. In 23 patients with metastases in regionally lymph nodes, seven had Her-2/neu overexpression. Among those seven patients, three developed distant metastasis (two women one year and in one woman two years after surgery) and all of them showed the presence of stromal IgG immunoreactivity and overexpression of calreticulin in their tumors tissue. Preliminary data showed that serum IgG immunoreactivity to tumor stroma in combination with overexpression of calreticulin in tumor cells correlate with postoperative appearance of metastases, particularly in the group of patients with Her-2/neu overexpressed tumors and metastases in axillary lymph nodes.
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ISSN:1219-4956
1532-2807
DOI:10.1007/s12253-008-9112-2