Plant thiol peroxidases as redox sensors and signal transducers in abiotic stress acclimation

• Published in: Free radical biology & medicine Vol. 193; no. Pt 2; pp. 764 - 778
• Main Authors: Vogelsang, Lara, Dietz, Karl-Josef
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.11.2022
• Subjects: Acclimatization; Glutathione; Glutathione peroxidase; Hydrogen Peroxide; NAD; Oxidants; Oxidation-Reduction; Peroxiredoxin; Peroxiredoxins - genetics; Reactive Oxygen Species; Redox regulatory network; Signaling; Stress, Physiological; Sulfhydryl Compounds; Glutathione peroxidase; Peroxiredoxin; Signaling; Hydrogen peroxide; Redox regulatory network
• ISSN: 0891-5849; 1873-4596
• DOI: 10.1016/j.freeradbiomed.2022.11.019

The temporal and spatial patterns of reactive oxygen species (ROS) in cells and tissues decisively determine the plant acclimation response to diverse abiotic and biotic stresses. Recent progress in developing dynamic cell imaging probes provides kinetic information on changes in parameters like H2O2, glutathione (GSH/GSSG) and NAD(P)H/NAD(P)+, that play a crucial role in tuning the cellular redox state. Central to redox-based regulation is the thiol-redox regulatory network of the cell that integrates reductive information from metabolism and oxidative ROS signals. Sensitive proteomics allow for monitoring changes in redox-related posttranslational modifications. Thiol peroxidases act as sensitive peroxide and redox sensors and play a central role in this signal transduction process. Peroxiredoxins (PRX) and glutathione peroxidases (GPX) are the two main thiol peroxidases and their function in ROS sensing and redox signaling in plants is emerging at present and summarized in this review. Depending on their redox state, PRXs and GPXs act as redox-dependent binding partners, direct oxidants of target proteins and oxidants of thiol redox transmitters that in turn oxidize target proteins. With their versatile functions, the multiple isoforms of plant thiol peroxidases play a central role in plant stress acclimation, e.g. to high light or osmotic stress, but also in ROS-mediated immunity and development. [Display omitted] •Thiol peroxidases play a crucial role in H2O2- and redox-dependent signaling.•Thiol peroxidases have five modes of action. Modes: tuning peroxide concentration, transmitter-dependent thiol oxidase, chaperone, covalent binder and contact thiol oxidase functions.