Hepatotoxicity associated with the use of a fixed combination of chloroquine and proguanil

Here we report on a case of hepatotoxicity associated with the use of a fixed combination of chloroquine and proguanil. Alternative causes of liver injury were excluded. The pathophysiological mechanism remains unclear, with a possibility of allergic reaction. In view of the widespread use of both d...

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Bibliographic Details
Published inInternational journal of antimicrobial agents Vol. 26; no. 2; pp. 176 - 178
Main Authors Wielgo-Polanin, R., Lagarce, L., Gautron, E., Diquet, B., Lainé-Cessac, P.
Format Journal Article
LanguageEnglish
Published London Elsevier B.V 01.08.2005
Amsterdam Elsevier
New York, NY
Subjects
Adverse Drug Reaction Reporting Systems
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimalarials - administration & dosage
Antimalarials - adverse effects
Biological and medical sciences
Chemical and Drug Induced Liver Injury
Chloroquine
Chloroquine - adverse effects
Chloroquine - pharmacology
Drug Combinations
Drug Interactions
Female
Hepatotoxicity
Humans
Malaria, Falciparum - drug therapy
Malaria, Falciparum - prevention & control
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Proguanil
Proguanil - adverse effects
Proguanil - pharmacology
Proguanil
Hepatotoxicity
Chloroquine
Antimalarial
Biguanides
Toxicity
Liver
Parasiticide
Antirheumatic agent
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Summary:Here we report on a case of hepatotoxicity associated with the use of a fixed combination of chloroquine and proguanil. Alternative causes of liver injury were excluded. The pathophysiological mechanism remains unclear, with a possibility of allergic reaction. In view of the widespread use of both drugs, clinicians should be aware of this drug-induced liver injury.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2005.04.019