Tirucallane Glycoside from the Leaves of Antidesma bunius and Inhibitory NO Production in BV2 Cells and RAW264.7 Macrophages

One new tirucallane-type triterpene glycoside, antidesoside (1), along with two biflavones, podocarpusflavone A (2) and amentoflavone (3) and two megastigmane glycosides, byzantionoside B (4), and (6S,9R)-roseoside (5) were isolated from the methanol extract of Antidesma bunius leaves. Their structu...

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Published inNatural product communications Vol. 11; no. 7; pp. 935 - 937
Main Authors Trang, Do Thi, Huyen, Le Thi, Nhiem, Nguyen Xuan, Quang, Tran Hong, Hang, Dan Thi Thuy, Yen, Pham Hai, Tai, Bui Huu, Anh, Hoang Le Tuan, Binh, Nguyen Quoc, Van Minh, Chau, Van Kiem, Phan
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.07.2016
Subjects
Animals
Cell Line
Euphorbiaceae - chemistry
Glycosides - chemistry
Macrophages - drug effects
Mice
Microglia - drug effects
Nitric Oxide
Plant Leaves - chemistry
BV2 cells
Euphorbiaceae
RAW264.7 macrophages
NO inhibitory
Antidesoside
Antidesma bunius
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Summary:One new tirucallane-type triterpene glycoside, antidesoside (1), along with two biflavones, podocarpusflavone A (2) and amentoflavone (3) and two megastigmane glycosides, byzantionoside B (4), and (6S,9R)-roseoside (5) were isolated from the methanol extract of Antidesma bunius leaves. Their structures were determined by spectroscopic methods and in comparison with the published data. Compounds 1 - 3 were found to show strong inhibitory effect of NO production in BV2 cells and RAW264.7 macrophages LPS-stimulated, with IC50 values ranging from 8.5 to 26.9 μM.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1601100717