Harnessing diverse transcriptional regulators for natural product discovery in fungi
Covering: Up to March 2019 Secondary metabolites (SMs) are chemical entities produced by organisms in response to environmental stimuli and as a defense against biological warfare. The production of SMs is controlled by a hierarchical regulatory network involving core factors that orchestrate transc...
Saved in:
| Published in | Natural product reports Vol. 37; no. 1; pp. 6 - 16 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
29.01.2020
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Summary: | Covering: Up to March 2019
Secondary metabolites (SMs) are chemical entities produced by organisms in response to environmental stimuli and as a defense against biological warfare. The production of SMs is controlled by a hierarchical regulatory network involving core factors that orchestrate transcriptional activation of SM gene clusters. In the past few years, significant achievements have been made in the discovery of novel fungal natural products by genetic manipulations of various types of transcriptional regulators. In this review, we summarized the representative regulators for the activation of fungal secondary metabolism and focused on the strategies for the exploitation of these regulators and their application in finding novel structures.
This review covers diverse transcriptional regulators for the activation of secondary metabolism and novel natural product discovery in fungi. |
|---|---|
| Bibliography: | Wen-Bing Yin is currently a Professor in the Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China. He obtained his PhD in Pharmaceutical Biology in 2009 from Philipps-University Marburg with Professor Shu-Ming Li where he studied the chemo-enzymatic biosynthesis of fungal natural products. Then he worked with Professor Nancy Keller as a post-doctoral fellow at the University of Wisconsin-Madison to study gene regulation on fungal secondary metabolism. After that, he moved to Los Angeles and worked with Professor Yi Tang at the University of California where he studied the discovery of natural products by a synthetic biological approach. In 2014, he returned to China to join the Institute of Microbiology and was supported by "the 100 Talents Project" of CAS. His research interests mostly focus on the activation, biosynthesis of silent fungal biosynthetic gene cluster and synthetic biological reconstruction of pharmaceutical molecules. Hai-Ning Lyu obtained his Bachelor's degree (2011) in Pharmaceutical Engineering from Beijing University of Chinese Medicine. He received his Master's (2014) and PhD degree (2017) in Natural Medicine at Peking University, under the supervision of Prof. Peng-Fei Tu and Prof. Yong Jiang. His doctoral research focused on the discovery of bioactive natural products from plants of the genera Murraya and Sinomenium. Currently, he works as a staff scientist in the Institute of Microbiology, Chinese Academy of Sciences, with Professor Wen-Bing Yin, where his research interests include the discovery, biosynthesis and metabolic engineering of natural products. Hong-Wei Liu is currently a Professor in the Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China. He obtained his PhD in medicinal chemistry in 2003 from Shenyang Pharmaceutical University with Professor Xin-Sheng Yao where he investigated the bioactive natural products from traditional Chinese medicine. Then he worked with Professor Guo-Ping Cai as a post-doctoral fellow at the Tsinghua University to study marine natural products. After that, he moved to Capital Medical University where he worked as an associated professor in the School of Pharmaceutical Sciences. In 2009, he joined the Institute of Microbiology and led a research team in the field of fungal natural products. His research interests mostly focus on the identification of novel bioactive fungal secondary metabolites, elucidation of biosynthetic pathway of fungal products, and generation of bioactive pharmaceutical agents by synthetic biology methods. Nancy Keller obtained her PhD degree in the Plant Pathology Department at Cornell University and is currently a Professor in the Department of Medical Microbiology and Immunology and Bacteriology at the University of Wisconsin. For her entire professional career, she has explored the genetics underlying fungal development with an emphasis on natural product synthesis in fungi. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ISSN: | 0265-0568 1460-4752 1460-4752 |
| DOI: | 10.1039/c8np00027a |