A potential mechanism for extracellular matrix induction of breast cancer cell normality

Extracellular matrix proteins from embryonic mesenchyme have a normalizing effect on cancer cells in vitro and slow tumor growth in vivo . This concept is suggestive of a new method for controlling the growth and spread of existing cancer cells in situ and indicates the possibility that extracellula...

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Bibliographic Details
Published inBreast cancer research : BCR Vol. 16; no. 1; p. 302
Main Authors Bruno, Robert D, Smith, Gilbert H
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 17.02.2014
BioMed Central
Subjects
Animals
Biglycan - chemistry
Breast Neoplasms - pathology
Cell Culture Techniques
Extracellular Matrix - metabolism
Female
Humans
Mammary Glands, Animal - embryology
Mesoderm - pathology
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Summary:Extracellular matrix proteins from embryonic mesenchyme have a normalizing effect on cancer cells in vitro and slow tumor growth in vivo . This concept is suggestive of a new method for controlling the growth and spread of existing cancer cells in situ and indicates the possibility that extracellular proteins and/or embryonic mesenchymal fibroblasts may represent a fertile subject for study of new anti-cancer treatments.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Commentary-3
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ISSN:1465-542X
1465-5411
1465-542X
DOI:10.1186/bcr3617