Functionalization of Ruthenium Olefin-Metathesis Catalysts for Interdisciplinary Studies in Chemistry and Biology

Hoveyda–Grubbs-type complexes, ruthenium catalysts for olefin metathesis, have gained increased interest as a research target in the interdisciplinary research fields of chemistry and biology because of their high functional group selectivity in olefin metathesis reactions and stabilities in aqueous...

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Bibliographic Details
Published inCatalysts Vol. 11; no. 3; p. 359
Main Author Matsuo, Takashi
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.03.2021
Subjects
Amino acids
Aqueous solutions
artificial metalloenzyme
Biology
Biomolecules
Catalysts
Chemical reactions
Decomposition reactions
Enzymes
Functional groups
Hoveyda–Grubbs catalyst
Interdisciplinary studies
Ligands
Metathesis
Mutation
Proteins
Ruthenium compounds
second-coordination sphere effect
Selectivity
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Summary:Hoveyda–Grubbs-type complexes, ruthenium catalysts for olefin metathesis, have gained increased interest as a research target in the interdisciplinary research fields of chemistry and biology because of their high functional group selectivity in olefin metathesis reactions and stabilities in aqueous media. This review article introduces the application of designed Hoveyda–Grubbs-type complexes for bio-relevant studies including the construction of hybrid olefin metathesis biocatalysts and the development of in-vivo olefin metathesis reactions. As a noticeable issue in the employment of Hoveyda–Grubbs-type complexes in aqueous media, the influence of water on the catalytic activities of the complexes and strategies to overcome the problems resulting from the water effects are also discussed. In connection to the structural effects of protein structures on the reactivities of Hoveyda–Grubbs-type complexes included in the protein, the regulation of metathesis activities through second-coordination sphere effect is presented, demonstrating that the reactivities of Hoveyda–Grubbs-type complexes are controllable by the structural modification of the complexes at outer-sphere parts. Finally, as a new-type reaction based on the ruthenium-olefin specific interaction, a recent finding on the ruthenium complex transfer reaction between Hoveyda–Grubbs-type complexes and biomolecules is introduced.
ISSN:2073-4344
2073-4344
DOI:10.3390/catal11030359