Expression of SARS-CoV-2 entry factors in lung epithelial stem cells and its potential implications for COVID-19

SARS-CoV-2 can infiltrate the lower respiratory tract, resulting in severe respiratory failure and a high death rate. Normally, the airway and alveolar epithelium can be rapidly reconstituted by multipotent stem cells after episodes of infection. Here, we analyzed published RNA-seq datasets and demo...

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Published inScientific reports Vol. 10; no. 1; p. 17772
Main Authors Valyaeva, Anna A, Zharikova, Anastasia A, Kasianov, Artem S, Vassetzky, Yegor S, Sheval, Eugene V
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 20.10.2020
Nature Publishing Group UK
Subjects
Angiotensin-Converting Enzyme 2
Betacoronavirus - isolation & purification
Betacoronavirus - physiology
Cell Differentiation
Cell Line
Coronavirus Infections - pathology
Coronavirus Infections - virology
COVID-19
Humans
Life Sciences
Lung - cytology
Pandemics
Peptidyl-Dipeptidase A - metabolism
Pneumonia, Viral - pathology
Pneumonia, Viral - virology
SARS-CoV-2
Serine Endopeptidases - metabolism
Stem Cells - cytology
Stem Cells - metabolism
Stem Cells - virology
Viral Proteins - genetics
Viral Proteins - metabolism
Virus Internalization
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Summary:SARS-CoV-2 can infiltrate the lower respiratory tract, resulting in severe respiratory failure and a high death rate. Normally, the airway and alveolar epithelium can be rapidly reconstituted by multipotent stem cells after episodes of infection. Here, we analyzed published RNA-seq datasets and demonstrated that cells of four different lung epithelial stem cell types express SARS-CoV-2 entry factors, including Ace2. Thus, stem cells can be potentially infected by SARS-CoV-2, which may lead to defects in regeneration capacity partially accounting for the severity of SARS-CoV-2 infection and its consequences.
Bibliography:ObjectType-Article-1
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-74598-5