Recent developments in strontium-based biocomposites for bone regeneration

• Published in: Journal of artificial organs Vol. 23; no. 3; pp. 191 - 202
• Main Authors: Zhang, Songou, Dong, Yongqiang, Chen, Meikai, Xu, Yifan, Ping, Jianfeng, Chen, Wangzhen, Liang, Wenqing
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.09.2020; Springer Nature B.V
• Subjects: Animals; Biocompatible Materials; Biomaterials; Biomedical Engineering and Bioengineering; Biomedical materials; Biomimetics; Bone biomaterials; Bone growth; Bone implants; Bone Regeneration - physiology; Bone remodeling; Calcium; Calcium Compounds; Calcium Phosphates; Calcium silicates; Cardiac Surgery; Ceramics; Composite materials; Drug delivery systems; Drug development; Growth factors; Humans; Medicine; Medicine & Public Health; Nephrology; Osteogenesis; Osteogenesis - physiology; Polymers; Regeneration; Regeneration (physiology); Review; Scaffolds; Silicates; Stem Cells; Strontium; Surgical implants; Tissue Scaffolds; Strontium; Bone; Biomimetic scaffold; Osteogenesis; Biocomposites; Biomaterials
• ISSN: 1434-7229; 1619-0904
• DOI: 10.1007/s10047-020-01159-y

Recent advances in biomaterial designing techniques offer immense support to tailor biomimetic scaffolds and to engineer the microstructure of biomaterials for triggering bone regeneration in challenging bone defects. The current review presents the different categories of recently explored strontium-integrated biomaterials, including calcium silicate, calcium phosphate, bioglasses and polymer-based synthetic implants along with their in vivo bone formation efficacies and/or in vitro cell responses. The role and significance of controlled drug release scaffold/carrier design in strontium-triggered osteogenesis was also comprehensively described. Furthermore, the effects of stem cells and growth factors on bone remodeling are also elucidated.