Cleavage of carbon-carbon bonds by radical reactions
In recent years, radical C-C bond cleavage reactions have been increasingly understood and used to perform transformations that complement traditional ionic processes. However, to date radical C-C bond cleavage/functionalization reactions have not been the subject of a dedicated review. Herein we su...
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| Published in | Chemical Society reviews Vol. 48; no. 9; pp. 2615 - 2656 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
07.05.2019
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| Subjects | |
| Online Access | Get full text |
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| Summary: | In recent years, radical C-C bond cleavage reactions have been increasingly understood and used to perform transformations that complement traditional ionic processes. However, to date radical C-C bond cleavage/functionalization reactions have not been the subject of a dedicated review. Herein we summarize the most recent and significant developments in the radical activation and functionalization of carbon-carbon bonds, with an emphasis on both synthetic outcomes and reaction mechanisms, and highlight how these radical C-C bond cleavage reactions enable challenging transformations.
This review provides insights into the
in situ
generated radicals triggered carbon-carbon bond cleavage reactions. |
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| Bibliography: | Xihe Bi started his independent research at the Northeast Normal University (China) at the end of 2008. Professor Bi's research team currently focuses on silver catalysis in organic synthesis. He has received honours and awards including the Young Scholar of the Changjiang Scholars Programme of China (2016), NSFC Foundation for Excellent Young Scientist (2015), Thieme Chemistry Journals Award (2014), and Alexander von Humboldt research fellowship (2006). Zikun Wang received his BSc from Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, in 2014. Then he worked as a research associate at Changchun Institute of Applied Chemistry, Chinese Academy of Sciences (China). In 2018, Wang joined the Department of Chemistry at Northeast Normal University (China), where he is now an Associate Professor. His research interests concern transition-metal-catalyzed transformations of alkynes. Paramasivam Sivaguru was born and brought up in Cuddalore, India, and received his BSc from Periyar Arts College (Cuddalore) affiliated to Thiruvalluvar University (India) in 2007. Then he moved to Periyar University (India), where he completed his MSc (2009), MPhil (2010) and PhD (2016) degrees under the direction of Professor A. Lalitha. He then joined as a postdoctoral researcher in the group of Professor Xihe Bi at Northeast Normal University (China) in 2017. His research interests include transition-metal-catalyzed activation of inert bonds. Giuseppe Zanoni received his BSc and PhD in chemistry from the University of Pavia, Italy. He also worked as a postdoc with BM Trost at Stanford University. After two years devoted to combinatorial chemistry at SmithKline-Beecham in Milan, he moved back to the University of Pavia, where he was promoted to an Associate Professor in 2011. His scientific interests are in the area of asymmetric synthesis, organometallic chemistry, novel PET probes, medicinal chemistry, and natural product chemistry. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ISSN: | 0306-0012 1460-4744 1460-4744 |
| DOI: | 10.1039/c8cs00386f |