Bone and vascular endothelial cells in cultures on nanocrystalline diamond films

• Published in: Diamond and related materials Vol. 17; no. 7; pp. 1405 - 1409
• Main Authors: Grausova, L., Kromka, A., Bacakova, L., Potocky, S., Vanecek, M., Lisa, V.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier B.V 01.07.2008; Elsevier
• Subjects: Bone implants; Carbon nanoparticles; Condensed matter: structure, mechanical and thermal properties; Cross-disciplinary physics: materials science; rheology; Exact sciences and technology; Fullerenes and related materials; diamonds, graphite; Materials science; Mechanical and acoustical properties; Methods of deposition of films and coatings; film growth and epitaxy; Nanocrystalline materials; Nanoscale materials and structures: fabrication and characterization; Nanotechnology; Physical properties of thin films, nonelectronic; Physics; Specific materials; Surfaces and interfaces; thin films and whiskers (structure and nonelectronic properties); Theory and models of film growth; Tissue engineering; Bone implants; Carbon nanoparticles; Tissue engineering; Nanotechnology; Biotechnology; Endothelial cell; Synthetic diamond; Roughness; Mechanical properties; Polystyrene; Adhesion; Carbon; Thin films; Nanoparticles; Ultrananocrystalline diamond; Growth mechanism; Osteoblast; Silicon; Cell cultures; Nanostructured materials; Tribology
• ISSN: 0925-9635; 1879-0062
• DOI: 10.1016/j.diamond.2008.02.008

The adhesion, growth and viability of human osteoblast-like MG 63 cells and bovine pulmonary artery endothelial CPAE cells were investigated in cultures grown on nanocrystalline diamond (NCD) films with either low surface roughness (RMS of 8.2 nm) or hierarchically organized surfaces made of nano-dimensional roughness NCD films deposited on Si surfaces with the original microroughness (RMS of 301.1 nm and 7.6 nm, respectively). The number and viability of both cell types on NCD films was similar to the values obtained on control tissue culture polystyrene dishes, or even better. It can be concluded that nanocrystalline diamond films give good support for adhesion and growth of osteogenic and endothelial cells, and could be used in tissue engineering applications.