Autism spectrum disorder, very-early onset schizophrenia, and child disintegrative disorder: the challenge of diagnosis. A case-report study

• Published in: Frontiers in psychiatry Vol. 14; p. 1212687
• Main Authors: Di Luzio, Michelangelo, Guerrera, Silvia, Pontillo, Maria, Lala, Maria Rosaria, Casula, Laura, Valeri, Giovanni, Vicari, Stefano
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 28.07.2023
• Subjects: autism spectrum disorder; case report; child disintegrative disorder; late regression; neurodevelopment; Psychiatry; very-early onset schizophrenia; case report; child disintegrative disorder; neurodevelopment; autism spectrum disorder; very-early onset schizophrenia; late regression
• ISSN: 1664-0640; 1664-0640
• DOI: 10.3389/fpsyt.2023.1212687

Autism spectrum disorder (ASD) in the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) contains several disorders previously present as distinct diagnoses in the DSM Revised Fourth Edition (DSM-IV-TR). These include child disintegrative disorder (CDD). The latter presents typical features, such as a late regression of developmental acquisitions. However, it also shows symptoms similar to ASD, and psychotic symptoms, such as very-early onset schizophrenia (VEOS), are described in the literature. In this case report we deepen the case of P., a child who presents a late regression, at 7 years old, associated with psychotic symptoms in the absence of organic alterations. The child was treated with antipsychotic drug therapy and cognitive behavioral therapy. P. was diagnosed with ASD with acute and late regression associated with psychotic symptoms. During the follow-up, there was a gradual improvement in the clinical conditions. Improvements were possible due to therapeutic intervention (pharmacological and psychotherapeutic) and/or the natural course of the disorder. The diagnostic difficulty of this case reflects a clinical complexity in which it is not easy to distinguish between neurodevelopmental and psychiatric aspects. Clinical cases such as that of P. emphasize the theme of the neurodevelopment continuum model in which neurodevelopmental and psychiatric disturbances can be considered within a pattern of pathological continuity.