Poland anomaly after in vitro fertilization

• Published in: Fertility and sterility Vol. 62; no. 6; pp. 1268 - 1270
• Main Authors: Avrech, Ori M., Merlob, Paul, Neri, Alexander, Kaplan, Boris, Ovadia, Jardena, Fisch, Benjamin
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.1994; Elsevier Science
• Subjects: Adult; Biological and medical sciences; Birth control; Embryo Transfer; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone - agonists; Gynecology. Andrology. Obstetrics; Humans; In vitro fertilization; Infant, Newborn; malformation; Medical sciences; Menotropins - therapeutic use; Poland anomaly; Poland Syndrome - diagnosis; Sterility. Assisted procreation; triplet; Triplets; In vitro fertilization; malformation; triplet; Poland anomaly; Human; Diseases of the osteoarticular system; Dysostosis; Congenital disease; Case study; In vitro fertilization embryo transfer; Striated muscle disease; Teratogénesis; Malformation; Complication; Upper limb; Child; Poland syndrome
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/S0015-0282(16)57198-2

To describe an extremely rare anomaly in an infant born after IVF-ET, and to assess its possible relationship to the artificial reproductive technology. Case report. Infertility and IVF Unit, in a tertiary academic medical center. A 31-year-old healthy patient with a 9-year history of secondary, unexplained infertility. Standard IVF-ET treatment cycle, using GnRH-a (short protocol) and hMG for controlled ovarian hyperstimulation. Poland anomaly (asymmetric thorax with absence of the right pectoralis major muscle, low set rudimentary right nipple, and very mild hypoplasia of the right upper limb) is described for the first time in an infant who is one of a trizygotic triplet after IVF treatment. In view of the currently held hypothesis concerning the pathogenesis of Poland anomaly, the possibility of a teratogen or an event related to the reproductive procedure as the cuase of this anomaly seems unlikely.