A new polymorphism in the GRP78 is not associated with HBV invasion

• Published in: World journal of gastroenterology : WJG Vol. 15; no. 39; pp. 4958 - 4961
• Main Authors: Zhu, Xiao, Wang, Yi, Tao, Tao, Li, Dong-Pei, Lan, Fei-Fei, Zhu, Wei, Xie, Dan, Kung, Hsiang-Fu
• Format: Journal Article
• Language: English
• Published: United States Institute of Oncology, Affiliated Tumor Hospital of Guangzhou Medical College, Guangzhou 510095, Guangdong Province, China 21.10.2009; State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China%State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China%Department of Digestive Diseases, Zibo Central Hospital, Zibo 255000, Shandong Province, China%Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China%Laboratory of Integrated Biosciences, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, Guangdong Province, China; The WJG Press and Baishideng
• Subjects: Adult; Alanine Transaminase - blood; Asian Continental Ancestry Group - genetics; Brief; Case-Control Studies; China - epidemiology; DNA, Viral - blood; Enzyme-Linked Immunosorbent Assay; Female; Gene Frequency; Genetic Predisposition to Disease; HBV; Heat-Shock Proteins - genetics; Hepatitis B - diagnosis; Hepatitis B - ethnology; Hepatitis B - genetics; Hepatitis B Antibodies - blood; Hepatitis B e Antigens - blood; Hepatitis B virus - genetics; Hepatitis B virus - immunology; Hepatitis B virus - pathogenicity; Humans; Logistic Models; Male; Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Risk Assessment; Young Adult; 乙型肝炎病毒; 基因分型; 基因多态性; 病毒DNA; 病毒入侵; 调节蛋白; 酶联免疫检测试剂盒; Glucose-regulated protein 78; Single-nucleotide polymorphism; Hepatitis B virus; Acute exacerbation
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.15.4958

AIM： To examine the association between -86 bp （T 〉 A） in the glucose-regulated protein 78 gene （GRP78） and hepatitis B virus （HBV） invasion. METHODS： DNA was genotyped for the single-nucleotide polymorphism by polymerase chain reaction followed by sequencing in a sample of 382 unrelated HBV carriers and a total of 350 sex- and age-matched healthy controls. Serological markers for HBV infection were determined by enzyme-linked immunosorbent assay kits or clinical chemistry testing. RESULTS： The distributions of allelotype and genotype in cases were not significantly different from those in controls. In addition, our findings suggested that neither alanine aminotransferase/hepatitis B e antigen nor HBV-DNA were associated with the allele/genotype variation in HBV infected individuals.CONCLUSION： -86 bp T 〉 A polymorphism in GRP78 gene is not related to the clinical risk and acute exacerbation of HBV invasion.