Sustained Consumption of a Decaffeinated Green Coffee Nutraceutical Has Limited Effects on Phenolic Metabolism and Bioavailability in Overweight/Obese Subjects

• Published in: Nutrients Vol. 14; no. 12; p. 2445
• Main Authors: Seguido, Miguel Ángel, Tarradas, Rosa Maria, González-Rámila, Susana, García-Cordero, Joaquín, Sarriá, Beatriz, Bravo-Clemente, Laura, Mateos, Raquel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.06.2022; MDPI
• Subjects: Acids; Bioavailability; Biological Availability; Coffee; Coffee - metabolism; decaffeination; Diet therapy; Dietary Supplements; excretion; feces; Functional foods; Functional foods & nutraceuticals; Health aspects; Humans; intestines; Metabolism; Metabolites; Microbiota; Nutrition research; Obesity; Overweight; Pharmacokinetics; Phenols; Phenols - metabolism; Solvents; Testing; Urine; Weight control; Yogurt; Spain; United States > US; Madrid Spain; pharmacokinetics; hydroxycinnamates; biotransformation pathways; bioavailability; microbial catabolites; green coffee
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu14122445

Knowledge on the bioavailability of coffee (poly)phenols mostly come from single dose postprandial studies. This study aimed at investigating the effects of regularly consuming a green coffee phenolic extract (GCPE) on the bioavailability and metabolism of (poly)phenols. Volunteers with overweight/obesity consumed a decaffeinated GCPE nutraceutical containing 300 mg hydroxycinnamates twice daily for two months. Plasma and urinary pharmacokinetics, and fecal excretion of phenolic metabolites were characterized by LC-MS-QToF at weeks 0 and 8. Fifty-four metabolites were identified in biological fluids. Regular consumption of the nutraceutical produced certain changes: reduced forms of caffeic, ferulic and coumaric acids in urine or 3-(3′-hydroxypenyl)propanoic, and 3,4-dihydroxybenzoic acids in feces significantly increased (p < 0.05) after 8 weeks; in contrast, coumaroylquinic and dihydrocoumaroylquinic acids in urine decreased (p < 0.05) compared to baseline excretion. The sum of intestinal and colonic metabolites increased after sustained consumption of GCPE, without reaching statistical significance, suggesting a small overall effect on (poly)phenols’ bioavailability.