The cycle pregnancy rate is normal in baboons with stage I endometriosis but decreased in primates with stage II and stage III-IV disease

• Published in: Fertility and sterility Vol. 66; no. 5; pp. 809 - 813
• Main Authors: D’Hooghe, Thomas M., Bambra, Charanjit S., Raeymaekers, Barbara M., Riday, Ahmed M., Suleman, Mbaruk A., Koninckx, Philippe R.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Elsevier Inc 01.11.1996; Elsevier Science
• Subjects: Abortion, Veterinary; Animals; Baboons; Biological and medical sciences; Birth control; endometriosis; Endometriosis - complications; Endometriosis - pathology; Female; fertility; Gynecology. Andrology. Obstetrics; Infertility, Female - etiology; Medical sciences; Papio; Pregnancy; prospective controlled study; Sterility. Assisted procreation; endometriosis; Baboons; prospective controlled study; fertility; pregnancy; Prognosis; Endometriosis; Female sterility; Papio anubis; Female genital diseases; Pregnancy; Papio cynocephalus; Vertebrata; Clinical stage; Mammalia; Animal; Primates; Simioidea; Uterine diseases
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/S0015-0282(16)58641-5

To test the hypothesis that fertility is reduced in baboons with endometriosis. Prospective controlled follow-up study. Institute of Primate Research, Nairobi, Kenya. Seventy-one baboons, including 34 controls (normal pelvis) and 37 animals with histologically proven endometriosis (16 spontaneous and 21 induced). Baboons with endometriosis had minimal (n=9), mild (n=14), moderate (n=7), or severe (n=7) disease. Seventy-one baboons were mated during 286cycles. Cycle fecundity rate, cycle pregnancy rate, cycle abortion rate. Cycle pregnancy rate (excluding spontaneous abortions) was 15% (44/286) and was comparable between controls (19%, 20/104) and baboons with endometriosis (13%, 24/182). The cycle pregnancy rates were 24%, 10%, 7.5%, and 12.5% in animals with minimal, mild, moderate, and severe endometriosis, respectively. The cycle pregnancy rate was significantly lower in baboons with stage III-IV endometriosis (9%, 6/64) and with stage II disease (10%, 7/73) than in animals with stage I endometriosis (24%, 11/45) or in controls with a normal pelvis (19%). The normal cycle pregnancy rate in baboons with stage I endometriosis and the decreased cycle pregnancy rate in baboons with stage II and stage III-IV disease suggest that fertility decreases with the stage of endometriosis in baboons.