The amyloid code

• Published in: Nature medicine Vol. 12; no. 7; pp. 747 - 751
• Main Author: Mandavilli, Apoorva
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 01.07.2006
• Subjects: Alzheimer Disease - drug therapy; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Alzheimer's disease; Amyloid - genetics; Amyloid beta-Peptides - genetics; Brain; Brain - pathology; Brain - physiopathology; Dementia disorders; Humans; Medical research; Memory Disorders - drug therapy; Memory Disorders - genetics; Models, Neurological; Neurons - pathology; Neurons - physiology; Proteins

For more than a decade, many scientists have believed that the amyloid-beta protein triggers a series of steps--dubbed the amyloid cascade--that leads to the memory loss and dementia in those afflicted with Alzheimer disease. But some researchers say that those who believe the amyloid cascade hypoth...